PEGylated Protein Drugs: Basic Science and Clinical Applications - Veronese, Francesco M.; SpringerLink (Online service) (Basel : Birkhäuser Basel : Imprint: Birkhäuser, 2009)
Preface PEGylated protein conjugates: A new class of therapeutics for the 21st century -- Protein PEGylation, basic science and biological applications -- Reactive PEGs for protein conjugation -- Rebridging disulphides: site-specific PEGylation by sequential bis-alkylation -- Enzymatic techniques for PEGylation of biopharmaceuticals -- The site-specific TGase-mediated PEGylation of proteins occurs at flexible sites -- Protein conjugates purification and characterization -- PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals -- The occurrence, induction, specificity and potential effect of antibodies against poly(ethylene glycol) -- Pegfilgrastim - designing an improved form of rmetHuG-CSF -- PEGylation of human growth hormone: strategies and properties -- PEGylated ? interferons: two different strategies to achieve increased efficacy -- Development of PEGylated mammalian urate oxidase as a therapy for patients with refractory gout -- Certolizumab pegol: a PEGylated anti-tumour necrosis factor alpha biological agent -- PEG: a useful technology in anticancer therapy -- Regulatory strategy and approval processes considered for PEG-drug conjugates and other nanomedicines.
Keywords: Pharmacology; Immunology; Biotechnology; Medical biochemistry; Medicinal chemistry; Pharmacology/Toxicology.; Immunology; Biotechnology; Medical Biochemistry; Medicinal Chemistry