Biochemistry and Molecular Biology of Antimicrobial Drug Action - Franklin, T.; SpringerLink (Online service) (Dordrecht : Springer Netherlands : Imprint: Springer, 1998)
1 The Development of Antimicrobial Agents Past, Present and Future -- 1.1 The social and economic importance of antimicrobial agents -- 1.2 An outline of the historical development of antimicrobial agents -- 1.3 Reasons for studying the biochemistry and molecular biology of antimicrobial compounds -- 1.4 Uncovering the molecular basis of antimicrobial action -- 1.5 Scope and layout of the present book -- 2 Vulnerable Shields - The Cell Walls of Bacteria and Fungi -- 2.1 Functions of the cell wall -- 2.2 Structure of the bacterial wall -- 2.3 Structure and biosynthesis of peptidoglycan -- 2.4 Antibiotics that inhibit peptidoglycan biosynthesis -- 2.5 Drugs that interfere with the biosynthesis of the cell wall of mycobacteria -- 2.6 The structure of the fungal cell wall -- 2.7 Inhibitors of the biosynthesis of the fungal cell wall -- 3 Antiseptics, Antibiotics and the Cell Membrane -- 3.1 Microbe killers: antiseptics and disinfectants -- 3.2 Polypeptide antibiotics -- 3.3 lonophoric antibiotics -- 3.4 Antifungal agents that interfere with the function and biosynthesis of membrane sterols -- 4 Inhibitors of Nucleic Acid Synthesis -- 4.1 Compounds affecting the biosynthesis and utilization of nucleotide precursors -- 4.2 Inhibitors of nucleic acid biosynthesis at the polymerization stage -- 5 Inhibitors of Protein Biosynthesis -- 5.1 Ribosomes -- 5.2 Stages in protein biosynthesis -- 5.3 Puromycin -- 5.4 Inhibitors of aminoacyl-tRNA formation -- 5.5 Inhibitors of initiation and translation -- 5.6 Inhibitors of peptide bond formation and translocation -- 5.7 Nitrofurantoin - a ribosomal poison? -- 5.8 Effects of inhibitors of 70S ribosomes on eukaryotic cells -- 6 Antimicrobial Drugs with other Modes of Action -- 6.1 Antibacterial agents -- 6.2 A unique antifungal antibiotic - griseofulvin -- 6.3 Antiviral agents -- 6.4 Antiprotozoal agents -- 7 Penetrating the Defences: How Antimicrobial Drugs Reach Their Targets -- 7.1 Cellular permeability barriers to drug penetration -- 7.2 Multidrug efflux in bacteria -- 7.3 Examples of the uptake of antibacterial drugs -- 7.4 Uptake of antimicrobial drugs by eukaryotic pathogens -- 8 The Genetic Basis of Resistance to Antimicrobial Drugs -- 8.1 Mutations and the origins of drug-resistance genes -- 8.2 Gene mobility and transfer in bacterial drug resistance -- 8.3 Global regulators of drug resistance in Gram-negative bacteria -- 9 Biochemical Mechanisms of Resistance to Antimicrobial Drugs -- 9.1 Enzymic inactivation of drugs -- 9.2 Modification of drug targets -- 9.3 Drug efflux pumps -- 9.4 Other mechanisms of resistance -- 9.5 Drug resistance and the future of chemotherapy.
Keywords: Biochemistry; Biochemistry, general; Science, Humanities and Social Sciences, multidisciplinary