Cancer Drug Discovery : Science and History /
| Autores principales: | , , , |
|---|---|
| Autor Corporativo: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2016.
|
| Edición: | 1st ed. 2016. |
| Materias: |
Tabla de Contenidos:
- Part Ⅰ. A Scientific Overview on Cancer
- 1. Advancements in Life Sciences and Characteristic Features of Cancer Cells
- 1.1 Characteristics of cancer cells
- 1.2 Characteristic interactions of cancer cells with neighboring cells and the tumor microenvironment
- 2. Advancement of the Science and History of Cancer and Anticancer Drugs
- Part Ⅱ. Cancer Drug Discovery – Types and History
- 3. Chronology of Anticancer Drug Development
- 3.1 A historical background of cancer chemotherapy
- 3.2 Development of the anticancer drug screening systems
- 3.3 Chronology of the anticancer drug development
- 3.4 Clinical application of anticancer drugs
- 4. Alkylating Anticancer Drugs
- 4.1 Classical alkylating drugs
- 4.2 Nonclassical alkylating drugs
- 4.3 Alkylating-like agents: platinum compounds
- 5. Antimetabolic Anticancer Drugs
- 5.1 Folic acid derivatives
- 5.2 Purine analogs
- 5.3 Pyrimidine analogs
- 6. Natural Product Anticancer Drugs
- 6.1 Plant-derived anticancer drugs
- 6.2 Anticancer antibiotics
- 7. Immunotherapeutic Anticancer Drugs and Other Miscellaneous Anticancer Drugs
- 7.1 Immunotherapeutic anticancer drugs
- 7.2 Other miscellaneous anticancer drugs
- 8. Hormonal Anticancer Drugs
- 8.1 Hormonal anti-prostate-cancer drugs
- 8.2 Hormonal anti-breast-cancer drugs
- 8.3 Other hormonal anticancer drugs
- 9. Molecular Targeted Anticancer Drugs
- 9.1 Tretinoin (all-trans retinoic acid, ATRA)
- 9.2 Bcr-Abl Inhibitors
- 9.3 EGFR inhibitors
- 9.4 HER2 inhibitors
- 9.5 Angiogenesis inhibitors
- 9.6 Other kinase inhibitors
- 9.7 mTOR inhibitors
- 9.8 Other targeted anticancer antibody drugs
- 9.9 Epigenetic anticancer drugs
- 9.10 Proteasome inhibitors
- 9.11 Vismodegib: hedgehog pathway blocker
- 10. Complications of Anticancer Drugs and Their Management
- 10.1 Chemotherapy-induced nausea and vomiting (CINV)
- 10.2 Myelotoxicity (bone marrow toxicity)
- 10.3 Chemotherapy-induced diarrhea
- 10.4 Chemotherapy-induced constipation
- 10.5 Chemotherapy-induced urinary toxicity
- 10.6 Chemotherapy-induced pulmonary toxicity
- 10.7 Chemotherapy-induced neurotoxicity
- 10.8 Chemotherapy-induced neurotoxicity
- 10.9 Chemotherapy-induced oral mucositis
- 10.10 Anorexia
- 10.11 Tumor lysis syndrome
- 10.12 Extravasation of anticancer drugs
- 10.13 Chemotherapy-induced skin toxicity
- Part Ⅲ. A Paradigm Shift in Cancer Research
- 11. Advancements in Bioscience and New Cancer Drugs
- 11.1. Development of cancer drugs according to scientific advancements
- 11.2. New anticancer drugs.