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03703nam a22003615i 4500 |
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000277852 |
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20210625150456.0 |
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cr nn 008mamaa |
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140422s2014 gw | s |||| 0|eng d |
| 020 |
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|a 9783642544521
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| 024 |
7 |
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|a 10.1007/978-3-642-54452-1
|2 doi
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| 040 |
|
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Chemical Biology of Nucleic Acids :
|b Fundamentals and Clinical Applications /
|c edited by Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski.
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| 250 |
|
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|a 1st ed. 2014.
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| 260 |
# |
# |
|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 2014.
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| 300 |
|
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|a XI, 599 p. 231 illus., 84 illus. in color. :
|b online resource.
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a RNA Technologies,
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| 505 |
0 |
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|a RNA as Major Components in Chemical Evolvable Systems -- How the Early Genetic Code Was Established? - Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems -- Isomerization of RNA Phosphodiester Linkages -- Effects of Ionic Liquid and Liposomes on the Structure, Stability and Function of Nucleic Acids -- Oxidative Damage on RNA Nucleobases -- Use of FRET to Study Dynamics of DNA Replication -- Design, Characterization and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds -- Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies -- Flexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids -- Sequence Selective Recognition of Double-Stranded RNA -- Determining Transient Nucleic Acid Structures by NMR -- Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties -- Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms -- Progress in Chemically Modified Nucleic Acid Aptamers -- Aptamers as Molecular Smugglers -- Biochemical Aspects of Subcellular RNA Transport and Localization -- Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications -- Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology -- Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges -- Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression -- Site Directed Spin Labelling of RNA for Distance Measurements by EPR -- Chemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells -- Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches -- DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics -- Peptides Targeting G-Quadruplex Structures -- Synthesis of Site-Specifically Modified Long-Mer RNAs -- Synthesis and Exon-Skipping Activity of Chemically-Modified RNAs -- mRNA and snRNA Cap Analogs: Synthesis and Applications -- Innovative Chemistry for Synthesis of Regular RNA, 5’-Triphosphate RNA or 5’-Capped RNA.
|
| 650 |
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0 |
|a Nucleic acids.
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| 650 |
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0 |
|a Molecular biology.
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| 650 |
|
0 |
|a Human genetics.
|
| 650 |
1 |
4 |
|a Nucleic Acid Chemistry.
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| 650 |
2 |
4 |
|a Molecular Medicine.
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| 650 |
2 |
4 |
|a Human Genetics.
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| 700 |
1 |
|
|a Erdmann, Volker A.
|e editor.
|
| 700 |
1 |
|
|a Markiewicz, Wojciech T.
|e editor.
|
| 700 |
1 |
|
|a Barciszewski, Jan.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|