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02675nam a22003615i 4500 |
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20210618134707.0 |
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151209s2015 gw | s |||| 0|eng d |
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|a 9783319199832
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| 024 |
7 |
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|a 10.1007/978-3-319-19983-2
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Chromosomal Translocations and Genome Rearrangements in Cancer /
|c edited by Janet D. Rowley, Michelle M. Le Beau, Terence H. Rabbitts.
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| 250 |
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|a 1st ed. 2015.
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| 260 |
# |
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2015.
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| 300 |
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|a IX, 490 p. 72 illus., 69 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 505 |
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|a Part I Introduction -- A short history of chromosome rearrangements and gene fusions in cancer -- Part II General -- Molecular genetics methods in discovery of chromosome structure -- Mechanism of recurrent chromosomal translocations -- Chromosome translocations, cancer initiation and clonal evolution -- Chromosomal fragile sites and cancer -- Copy number changes in carcinomas: applications -- Part III LEUKAEMIA/LYMPHOMA -- Chronic myeloid leukaemia -- Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis -- Genetic alterations in B cell lymphoma -- Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia -- Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies -- Acute promyelocytic leukaemia: from a specific translocation to cure by targeted therapies -- Chromosome Abnormalities in AML and their clinical importance -- PART IV SARCOMAS -- Fusion Oncogenes of Sarcomas -- Translocations in Ewing Sarcoma -- PART V EPITHELIAL TUMOURS -- RET and thyroid carcinomas -- Gene fusions in prostate cancer -- Chromosomal Translocations in Lung Cancer -- Colon & Ovarian translocations -- PART VI OTHER ASPECTS -- Pre-clinical modeling of chromosomal translocations and inversions -- Protein complex hierarchy & translocation gene products -- Aberrant transcriptional programming in blood cancers -- Index.
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| 650 |
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0 |
|a Cancer research.
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| 650 |
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0 |
|a Cell biology.
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| 650 |
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|a Human genetics.
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| 650 |
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|a Molecular biology.
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| 650 |
1 |
4 |
|a Cancer Research.
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| 650 |
2 |
4 |
|a Cell Biology.
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| 650 |
2 |
4 |
|a Human Genetics.
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| 650 |
2 |
4 |
|a Molecular Medicine.
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| 700 |
1 |
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|a Rowley, Janet D.
|e editor.
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| 700 |
1 |
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|a Le Beau, Michelle M.
|e editor.
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| 700 |
1 |
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|a Rabbitts, Terence H.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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