Chromosomal Translocations and Genome Rearrangements in Cancer /
| Autor Corporativo: | |
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| Otros Autores: | , , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Cham :
Springer International Publishing : Imprint: Springer,
2015.
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| Edición: | 1st ed. 2015. |
| Materias: |
Tabla de Contenidos:
- Part I Introduction
- A short history of chromosome rearrangements and gene fusions in cancer
- Part II General
- Molecular genetics methods in discovery of chromosome structure
- Mechanism of recurrent chromosomal translocations
- Chromosome translocations, cancer initiation and clonal evolution
- Chromosomal fragile sites and cancer
- Copy number changes in carcinomas: applications
- Part III LEUKAEMIA/LYMPHOMA
- Chronic myeloid leukaemia
- Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis
- Genetic alterations in B cell lymphoma
- Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia
- Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies
- Acute promyelocytic leukaemia: from a specific translocation to cure by targeted therapies
- Chromosome Abnormalities in AML and their clinical importance
- PART IV SARCOMAS
- Fusion Oncogenes of Sarcomas
- Translocations in Ewing Sarcoma
- PART V EPITHELIAL TUMOURS
- RET and thyroid carcinomas
- Gene fusions in prostate cancer
- Chromosomal Translocations in Lung Cancer
- Colon & Ovarian translocations
- PART VI OTHER ASPECTS
- Pre-clinical modeling of chromosomal translocations and inversions
- Protein complex hierarchy & translocation gene products
- Aberrant transcriptional programming in blood cancers
- Index.