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03175nam a22004095i 4500 |
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000278953 |
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20201214142242.0 |
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cr nn 008mamaa |
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110301s2011 xxu| s |||| 0|eng d |
| 020 |
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|a 9781441969569
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| 024 |
7 |
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|a 10.1007/978-1-4419-6956-9
|2 doi
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| 040 |
|
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a BetaSys :
|b Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells /
|c edited by Bernhelm Booß-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström.
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| 250 |
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|a 1st ed. 2011.
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| 260 |
# |
# |
|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2011.
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| 300 |
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|a XX, 556 p. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Systems Biology,
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| 505 |
0 |
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|a Preface -- Systems biology of β-cells - revisited -- Established facts and open questions of the focused systems analysis of regulated exocytosis in β-cells – a background for a focused systems analysis approach -- Mitochondria and metabolic signals in β-cells -- β-cell ontogenesis and the insulin production apparatus -- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic β-cells -- The mathematical microscope making the inaccessible accessible -- Magnetic resonance imaging of pancreatic β-cells -- Mapping the β-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches -- In vivo applications of inorganic nanoparticles -- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts -- Bioimpedance spectroscopy -- DNA variations, impaired insulin secretion and type-2 diabetes -- Genetically programmed defects in β-cell function -- Proteomic analysis of the pancreatic islet β-cell secretory granule: current understanding and future opportunities -- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes -- Present state of islet transplantation for type-1 diabetes patients -- Predictive protein networks and identification of drugable targets in the β-cell -- Nanotoxicity -- From silicon cell to silicon human -- Probing cellular dynamics with mesoscopic simulations -- What drives calcium oscillations in β-cells? new tasks for cyclic analysis -- Whole-body and cellular models of glucose-stimulated insulin secretion -- Geometric and electromagnetic aspects of fusion pore making -- Index.
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| 650 |
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0 |
|a Systems biology.
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| 650 |
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0 |
|a Human genetics.
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| 650 |
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0 |
|a Bioinformatics.
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| 650 |
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0 |
|a Diabetes.
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| 650 |
1 |
4 |
|a Systems Biology.
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| 650 |
2 |
4 |
|a Human Genetics.
|
| 650 |
2 |
4 |
|a Bioinformatics.
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| 650 |
2 |
4 |
|a Diabetes.
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| 700 |
1 |
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|a Booß-Bavnbek, Bernhelm.
|e editor.
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| 700 |
1 |
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|a Klösgen, Beate.
|e editor.
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| 700 |
1 |
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|a Larsen, Jesper.
|e editor.
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| 700 |
1 |
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|a Pociot, Flemming.
|e editor.
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| 700 |
1 |
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|a Renström, Erik.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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