Cancer Biology and the Nuclear Envelope : Recent Advances May Elucidate Past Paradoxes /

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Schirmer, Eric C. (Editor), de las Heras, Jose I. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2014.
Edition:1st ed. 2014.
Series:Advances in Experimental Medicine and Biology, 773
Subjects:
Table of Contents:
  • Section I: History and use of the nuclear envelope in cancer prognosis: Overview and perspective
  • Cancer and the nuclear envelope, a history and perspective
  • The role of the nuclear lamina in cancer and apoptosis
  • The diagnostic pathology of the nuclear envelope in human cancers
  • Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer
  • "To be or not to be in good shape": diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer
  • Section II: The nuclear envelope in cell cycle regulation and signaling
  • pRb and lamins in cell cycle regulation and aging
  • Lamina-associated polypeptide (LAP)2a and other LEM proteins in cancer biology
  • NETs and cell cycle regulation
  • Nuclear envelope regulation of signaling cascades
  • Section III: Nuclear envelope regulation of the genome
  • Nuclear envelope - connecting structural genome organization to regulation of gene expression
  • Studying lamins in invertebrate models
  • Lamin organization of chromosome positioning
  • Section IV: Functions of the NPC in cancer
  • NPC proteins linked in cancer overview
  • Roles of the nucleoporin Tpr in cancer and aging.- Ran GTPase in nuclear envelope formation and cancer metastasis
  • Wnt signaling proteins associate with the nuclear pore complex: implications for cancer
  • Section V: The nuclear envelope in DNA damage and stress responses
  • DNA damage and lamins
  • Repo-Man at the intersection of chromatin remodeling, DNA repair, nuclear envelope organization and cancer progression
  • Lamines and oxygen stress damage in cell proliferation.- Section VI: The nuclear envelope link to cell migration and metastasis
  • Nuclear mechanics in cancer
  • Nuclear envelope in nuclear positioning and cell migration
  • Nesprins in cell stability and migration
  • Connecting the nucleus to the cytoskeleton for nuclear positioning and call migration
  • Section VII: Towards a molecular explanation of prognostic links to the nuclear envelope
  • Nuclear envelope invaginations and cancer
  • Mechanisms of nuclear size regulation in model systems and cancer
  • Control of nuclear size by NPC proteins
  • Do lamins influence disease progression in cancer?.   .