Drug Design : Methodology, Concepts, and Mode-of-Action /
| Autor principal: | |
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| Autor Corporativo: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2013.
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| Edición: | 1st ed. 2013. |
| Materias: |
Tabla de Contenidos:
- Part I Fundamentalsin Drug Research
- 1. Drug Research Yesterday, Today and Tomorrow
- 2. The Role of Serendipityin Drug Research
- 3. Classical Drug Research
- 4. Protein–Ligand Interactionsas the Basis for Drug Action
- 5. Optical Activity and Biological Effects
- Part II Discovery and Optimizationof Lead Compounds
- 6. Screeningfor Lead Structures
- 7. Screening Technologies for LeadDiscovery
- 8. Optimizationof Lead Structures
- 9. Designingprodrugs
- 10. Peptidomimetics
- Part III Experimental and Theoretical Methods
- 11. Combinatorics: Chemistry With Big Numbers
- 12. Gene Technology in drug research
- 13. Experimental Methods of Structure Determination
- 14. The Spatial Structure of Biomolecules
- 15. Molecular Modelling
- 16. Conformational Analysis
- Part IV Structure–Activity Relationships and Design Approaches
- 17.Pharmacophore Hypothesis and Molecular Comparisons
- 18. Quantitative Structure–ActivityRelationships
- 19. From in vitro to in vivo:Optimization of ADME-Tox Properties
- 20. ProteinModeling and Structure-BasedDrug Design
- 21. ACase Study: Structure-Based Inhibtor Design for tRNA-Guanine Transglycosylase
- Part V. Drugs and drug action: Successes of stucture-based design
- 22. Howdrugs act: Concepts for therapy
- 23. Inhibitors of hydrolases With an acyl-enzymeintermediate
- 24. Asparticprotease inhibitors
- 25. Inhibitorsof hydrolysing metalloenzymes
- 26. Inhibitorsof transferases
- 27. Inhibitors ofoxidoreductases
- 28. Agonists and antagonistsof nuclear receptors
- 29. Agonists and antagonists of membrane-bound
- 30. Ligands forchannels, pores and transporters
- 31. Ligands for surfacereceptors
- 32. Biologicals: Peptides, proteins, nucleotidesand macrolides as drugs.