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02570nam a22003015i 4500 |
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20210505081641.0 |
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100715s2010 xxu| s |||| 0|eng d |
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|a 9781603274180
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| 024 |
7 |
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|a 10.1007/978-1-60327-418-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Drug-DNA Interaction Protocols /
|c edited by Keith R. Fox.
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| 250 |
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|a 2nd ed. 2010.
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| 260 |
# |
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|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2010.
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| 300 |
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|a IX, 311 p. 103 illus., 1 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 613
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| 505 |
0 |
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|a Quantitative Analysis of Small Molecule–Nucleic Acid Interactions with a Biosensor Surface and Surface Plasmon Resonance Detection -- Thermal Melting Studies of Ligand DNA Interactions -- Circular and Linear Dichroism of Drug-DNA Systems -- Drug Binding to DNA?RNA Hybrid Structures -- Quantification of Binding Data Using Capillary Electrophoresis -- Determination of Equilibrium Association Constants of Ligand–DNA Complexes by Electrospray Mass Spectrometry -- Detection of Adriamycin-DNA Adducts by Accelerator Mass Spectrometry -- Molecular Modelling Methods to Quantitate Drug-DNA Interactions -- Application of Anomalous Diffraction Methods to the Study of DNA and DNA-Complexes -- DNase I Footprinting -- Methods to Characterize the Effect of DNA-Modifying Compounds on Nucleosomal DNA -- REPSA: Combinatorial Approach for Identifying Preferred Drug-DNA Binding Sequences -- In vitro Transcription Assay for Resolution of Drug-DNA Interactions at Defined DNA Sequences -- In vitro Footprinting of Promoter Regions Within Supercoiled Plasmid DNA -- Topoisomerase I-Mediated DNA Relaxation as a Tool to Study Intercalation of Small Molecules into Supercoiled DNA -- A High-Throughput Assay for DNA Topoisomerases and Other Enzymes, Based on DNA Triplex Formation -- Measurement of DNA Interstrand Crosslinking in Individual Cells Using the Single Cell Gel Electrophoresis (Comet) Assay -- Measurement of DNA Interstrand Crosslinking in Naked DNA Using Gel-Based Methods -- An Evaluation Cascade for G-Quadruplex Telomere Targeting Agents in Human Cancer Cells.
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| 650 |
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|a Pharmacology.
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| 650 |
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0 |
|a Human genetics.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 650 |
2 |
4 |
|a Human Genetics.
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| 700 |
1 |
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|a Fox, Keith R.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
|