Enzyme Kinetics in Drug Metabolism : Fundamentals and Applications /
| Autor Corporativo: | |
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| Otros Autores: | , , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2014.
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| Edición: | 1st ed. 2014. |
| Colección: | Methods in Molecular Biology,
1113 |
| Materias: |
Tabla de Contenidos:
- Enzyme Kinetics in Drug Metabolism – Fundamentals and Applications
- Fundaments of Enzyme Kinetics
- Different Enzyme Kinetic Models
- Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance
- Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions
- Multi-Enzyme Kinetics and Sequential Metabolism
- Consideration of the Unbound Drug Concentration in Enzyme Kinetics
- Enzyme Kinetics of Oxidative Metabolism – Cytochromes P450
- Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase
- Enzyme Kinetics of Conjugative Enzymes – PAPS
- Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)
- Principles and Experimental Considerations for in vitro Transporter Interaction Assays
- Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data – from in vitro Tools to Mechanistic Modeling
- The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
- Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
- Variability in Human in vitro Enzyme Kinetics
- Sources of Interindividual Variability
- Case Study 1. Practical Considerations with Experimental Design and Interpretation
- Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies
- Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies – Real Life Examples
- Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast
- Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development
- Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes
- Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors’ Experiences.