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151126s2016 xxu| s |||| 0|eng d |
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|a 9781493932719
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| 024 |
7 |
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|a 10.1007/978-1-4939-3271-9
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Gene Therapy for Neurological Disorders :
|b Methods and Protocols /
|c edited by Fredric P. Manfredsson.
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| 250 |
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|a 1st ed. 2016.
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| 260 |
# |
# |
|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2016.
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| 300 |
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|a XIV, 493 p. 83 illus., 65 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1382
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| 505 |
0 |
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|a Introduction to Viral Vectors and Other Delivery Methods for Gene Therapy of the Nervous System.- Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors -- Expression of Multiple Functional RNAs or Proteins from One Viral Vector.- Regulated Gene Therapy.- Design of shRNA and miRNA for Delivery to the CNS.- Tissue Specific Promoters in the CNS.- Small Scale Recombinant Adeno-Associated Virus Purification.- Lentivirus Production and Purification.- Viral Vector Production: Adenovirus.- Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids.- Altering Tropism of rAAV by Directed Evolution.- Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins.- Directed Evolution of Adenoviruses.- Intraparenchymal Stereotaxic Delivery of rAAV and Special Considerations in Vector Handling.- MRI-Guided Delivery of Viral Vectors.- Systemic Gene Therapy for Targeting the CNS -- Widespread Neuronal Transduction of the Rodent CNS via Neonatal Viral Injection.- AAV-Mediated Gene Transfer to Dorsal Root Ganglion.- Gene Therapy of the Peripheral Nervous System: The Enteric Nervous System.- Gene Therapy of the Peripheral Nervous System: Celiac Ganglia.- Convection Enhanced Delivery of Recombinant Adeno-Associated Virus into the Mouse Brain.- Non-Viral Gene Therapy of the Nervous System: Electroporation.- Non-Viral, Lipid-Mediated DNA and mRNA Gene Therapy of the Central Nervous System (CNS): Chemical-Based Transfection.- Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model.- Gene Therapy Models of Alzheimer’s Disease and Other Dementias.- Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson’s Disease.- Gene Therapy-Based Modeling of Neurodegenerative Disorders: Huntington's Disease.- Gene Therapy for the Treatment of Neurological Disorders: Amyotrophic Lateral Sclerosis.- Stereotaxic Surgical Targeting of the Non-Human Primate Causate and Putamen: Gene Therapy for Huntington’s Disease.- Gene-Therapy for the Treatment of Neurological Disorders: Metabolic Disorders.- Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms.- AAV2-Neurturin for Parkinson’s Disease: What Lessons Have We Learned?.
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| 650 |
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0 |
|a Neurosciences.
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| 650 |
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0 |
|a Human genetics.
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| 650 |
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0 |
|a Neurology .
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| 650 |
1 |
4 |
|a Neurosciences.
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| 650 |
2 |
4 |
|a Human Genetics.
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| 650 |
2 |
4 |
|a Neurology.
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| 700 |
1 |
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|a Manfredsson, Fredric P.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
|