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03417nam a22003135i 4500 |
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cr nn 008mamaa |
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180531s2018 xxu| s |||| 0|eng d |
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|a 9781493978250
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| 024 |
7 |
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|a 10.1007/978-1-4939-7825-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Huntington's Disease /
|c edited by Sophie V. Precious, Anne E. Rosser, Stephen B. Dunnett.
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| 250 |
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|a 1st ed. 2018.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2018.
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| 300 |
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|a XV, 642 p. 111 illus., 74 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1780
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| 505 |
0 |
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|a Stereological Methods to Quantify Cell Loss in the Huntington's Disease Human Brain -- Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells -- A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples -- Cellular Models: HD Patient-Derived Pluripotent Stem Cells -- Non-Mammalian Models of Huntington's Disease -- Mouse Models of Huntington's Disease -- Motor Assessment in Huntington's Disease Mice -- Automated Operant Assessments of Huntington's Disease Mouse Models -- Neurophysiological Assessment of Huntington's Disease Model Mice -- Murine Models of Huntington's Disease for Evaluating Therapeutics -- Generating Excitotoxic Lesion Models of Huntington's Disease -- Large-Brained Animal Models of Huntington's Disease: Sheep -- Minipigs as Large-Brained Animal Model for Huntington's Disease: From Behavior and Imaging to Gene Therapy -- Non-Human Primate Models of Huntington's Disease and Their Application in Translational Research -- In Vivo Multidimensional Brain Imaging in Huntington's Disease Animal Models -- Magnetic Resonance Imaging in Huntington's Disease -- Biofluid Biomarkers in Huntington's Disease -- Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase -- Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington's Disease -- Using Genomic Data to Find Disease-Modifying Loci in Huntington's Disease (HD).-CRISPR/Cas9-Mediated Genome Editing for Huntington's Disease -- Methods for Assessing DNA Repair and Repeat Expansion in Huntington's Disease -- Translating Antisense Technology into a Treatment for Huntington's Disease -- Disease Modification through Trophic Factor Delivery -- Methods to Quantify Cell Signaling and GPCR Receptor Ligand Bias: Characterization of Drugs that Target the Endocannabinoid Receptors in Huntington's Disease -- Dissection and Preparation of Human Primary Fetal Ganglionic Eminence Tissue for Research and Clinical Application -- Robust Induction of DARPP32-Expressing GABAergic Striatal Neurons from Human Pluripotent Stem Cells -- Quality Assessment and Production of Human Cells for Clinical Use.
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| 650 |
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0 |
|a Neurosciences.
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| 650 |
1 |
4 |
|a Neurosciences.
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| 700 |
1 |
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|a Precious, Sophie V.
|e editor.
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| 700 |
1 |
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|a Rosser, Anne E.
|e editor.
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| 700 |
1 |
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|a Dunnett, Stephen B.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|