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03520nam a22003015i 4500 |
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20201013104320.0 |
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cr nn 008mamaa |
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180723s2018 xxu| s |||| 0|eng d |
| 020 |
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|a 9781493986309
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| 024 |
7 |
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|a 10.1007/978-1-4939-8630-9
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Rational Drug Design :
|b Methods and Protocols /
|c edited by Thomas Mavromoustakos, Tahsin F. Kellici.
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| 250 |
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|a 1st ed. 2018.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2018.
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| 300 |
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|a XIV, 465 p. 148 illus., 124 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1824
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| 505 |
0 |
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|a Conformational Properties of hIAPP22-29 (NFGAILSS) and Rational Drug Design -- Electronic and Electrostatic Approaches to the Development of Peptide-based Inhibitors of Amylin Aggregation -- In Silico Drug Design: Applications of non-peptide mimetics towards the immunotherapy of multiple sclerosis -- Binding Moiety Mapping by Saturation Transfer Difference NMR -- Protein Ligand Docking in Drug Design: Performance Assessment and Binding-Pose Selection -- Rational Drug Design using Integrative Structural Biology -- Enalos+Knime Nodes: New Cheminformatics Tools for Drug Discovery -- Bioguided Design of Trypanosomicidal Compounds: A Successful Strategy in Drug Discovery -- A Hybrid Virtual Screening Protocol Based on Binding Mode Similarity -- Single Step Determination of Unlabelled Compound Kinetics Using a Competition Association Binding Method Employing Time-resolved FRET -- Dynamic Undocking: A Novel Method for Structure-based Drug Discovery -- The impact of Lipophilicity in Drug Discovery – Rapid Measurements by Means of Reversed Phase HPLC -- Exploring Polypharmacology in Drug Design -- Development of Nuclear Receptor Modulators -- In silico Screening of Compound Libraries using a Consensus of Orthogonal Methodologies -- Insights in Organometallic Synthesis of Various Adamantane Derivatives with Sigma Receptor (σR) Binding Affinity and Antiproliferative / Anticancer Activity -- Supervised Molecular Dynamics (SuMD) Approaches in Drug Design -- Lead Identification through the Synergistic Action of Biomolecular NMR and in Silico Methodologies -- The use of Dynamic Pharmacophore in Computer Aided Hit Discovery: A Case Study -- Rational Design of MAGL inhibitors -- Application of Virtual Screening Approaches for the Identification of Small Molecule Inhibitors of the methyllysine Reader Protein Spindlin1 -- Designing Natural Product Hybrids Bearing Triple Antiplatelet Profile and Enhanced Human Plasma Stability -- Pharmacophore Generation and 3D-QSAR Model Development using PHASE -- Design of Drugs by Filtering through ADMET, Physicochemical, and Ligand-Target Flexibility Properties -- Reactions in NMR tubes as Key Weapon in Rational Drug Design -- Application of Multiscale Simulations Tools on GPCRs. An Example with Angiotensin-II type 1 receptor -- Angiotensin II Type 1 Receptor Homology Models: A Comparison between In Silico and the Crystal Structures. .
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| 650 |
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|a Pharmacology.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 700 |
1 |
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|a Mavromoustakos, Thomas.
|e editor.
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| 700 |
1 |
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|a Kellici, Tahsin F.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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