|
|
|
|
| LEADER |
03066nam a22003615i 4500 |
| 001 |
000287806 |
| 005 |
20201008135840.0 |
| 007 |
cr nn 008mamaa |
| 008 |
190813s2019 xxu| s |||| 0|eng d |
| 020 |
|
|
|a 9781493996704
|
| 024 |
7 |
|
|a 10.1007/978-1-4939-9670-4
|2 doi
|
| 040 |
|
|
|a Sistema de Bibliotecas del Tecnológico de Costa Rica
|
| 245 |
1 |
0 |
|a Oligonucleotide-Based Therapies :
|b Methods and Protocols /
|c edited by Olof Gissberg, Rula Zain, Karin E. Lundin.
|
| 250 |
|
|
|a 1st ed. 2019.
|
| 260 |
# |
# |
|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2019.
|
| 300 |
|
|
|a XI, 344 p. 69 illus., 46 illus. in color. :
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a Methods in Molecular Biology,
|v 2036
|
| 505 |
0 |
|
|a Chemical Development of Therapeutic Oligonucleotides -- Tissue-Specific Delivery of Oligonucleotides -- Designing siRNA and Evaluating Its Effect on RNA Targets Using qPCR and Western Blot -- Antisense Oligonucleotides for Splice Modulation: Assessing Splice Switching Efficacy -- Assessing Oligonucleotide Binding to Double-Strand DNA -- Modelling and Simulation of Oligonucleotide Hybrids: Outlining a Strategy -- Characterization of Peptide/Oligonucleotide Complexes Using Electron Microscopy, Dynamic Light Scattering, and Protease Resistance Assay -- Click-Shielded and Targeted Lipopolyplexes -- Attachment of Peptides to Oligonucleotides on Solid Support Using Copper(I)-Catalyzed Huisgen 1,3-Dipolar Cycloaddition -- Characterizing Oligonucleotide Uptake in Cultured Cells: A Case Study Using AS1411 Aptamer -- Measuring the Action of Oligonucleotide Therapeutics in the Lung at the Cell Type-Specific Level by Tissue Disruption and Cell Sorting (TDCS) -- Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro and In Vivo Application in the Context of Spinal Cord Injury -- Evaluation of Cell-Penetrating Peptide Delivery of Antisense Oligonucleotides for Therapeutic Efficacy in Spinal Muscular Atrophy -- Injection and Infusion of Compounds to the Central Nervous System -- In Vitro Assessment of the Hepatotoxicity Potential of Therapeutic Oligonucleotides -- Identifying Suitable Target Regions and Analyzing Off-Target Effects -- RACE-SEQ and Population-Wide Polymorphism Susceptibility Testing for Endonucleolytically Active, RNA-Targeting Therapeutics -- Studying the Biotransformation of Phosphorothioate-Containing Oligonucleotide Drugs by LC-MS -- ADME: Assessing Pharmacokinetic-Pharmacodynamic Parameters of Oligonucleotides.
|
| 650 |
|
0 |
|a Laboratory medicine.
|
| 650 |
|
0 |
|a Human genetics.
|
| 650 |
|
0 |
|a Pharmacology.
|
| 650 |
1 |
4 |
|a Laboratory Medicine.
|
| 650 |
2 |
4 |
|a Human Genetics.
|
| 650 |
2 |
4 |
|a Pharmacology/Toxicology.
|
| 700 |
1 |
|
|a Gissberg, Olof.
|e editor.
|
| 700 |
1 |
|
|a Zain, Rula.
|e editor.
|
| 700 |
1 |
|
|a Lundin, Karin E.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 900 |
|
|
|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|