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03066nam a22003615i 4500 |
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000287806 |
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20201008135840.0 |
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190813s2019 xxu| s |||| 0|eng d |
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|a 9781493996704
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024 |
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|a 10.1007/978-1-4939-9670-4
|2 doi
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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245 |
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|a Oligonucleotide-Based Therapies :
|b Methods and Protocols /
|c edited by Olof Gissberg, Rula Zain, Karin E. Lundin.
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250 |
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|a 1st ed. 2019.
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260 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2019.
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300 |
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|a XI, 344 p. 69 illus., 46 illus. in color. :
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Methods in Molecular Biology,
|v 2036
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|a Chemical Development of Therapeutic Oligonucleotides -- Tissue-Specific Delivery of Oligonucleotides -- Designing siRNA and Evaluating Its Effect on RNA Targets Using qPCR and Western Blot -- Antisense Oligonucleotides for Splice Modulation: Assessing Splice Switching Efficacy -- Assessing Oligonucleotide Binding to Double-Strand DNA -- Modelling and Simulation of Oligonucleotide Hybrids: Outlining a Strategy -- Characterization of Peptide/Oligonucleotide Complexes Using Electron Microscopy, Dynamic Light Scattering, and Protease Resistance Assay -- Click-Shielded and Targeted Lipopolyplexes -- Attachment of Peptides to Oligonucleotides on Solid Support Using Copper(I)-Catalyzed Huisgen 1,3-Dipolar Cycloaddition -- Characterizing Oligonucleotide Uptake in Cultured Cells: A Case Study Using AS1411 Aptamer -- Measuring the Action of Oligonucleotide Therapeutics in the Lung at the Cell Type-Specific Level by Tissue Disruption and Cell Sorting (TDCS) -- Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro and In Vivo Application in the Context of Spinal Cord Injury -- Evaluation of Cell-Penetrating Peptide Delivery of Antisense Oligonucleotides for Therapeutic Efficacy in Spinal Muscular Atrophy -- Injection and Infusion of Compounds to the Central Nervous System -- In Vitro Assessment of the Hepatotoxicity Potential of Therapeutic Oligonucleotides -- Identifying Suitable Target Regions and Analyzing Off-Target Effects -- RACE-SEQ and Population-Wide Polymorphism Susceptibility Testing for Endonucleolytically Active, RNA-Targeting Therapeutics -- Studying the Biotransformation of Phosphorothioate-Containing Oligonucleotide Drugs by LC-MS -- ADME: Assessing Pharmacokinetic-Pharmacodynamic Parameters of Oligonucleotides.
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650 |
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|a Laboratory medicine.
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650 |
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|a Human genetics.
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650 |
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|a Pharmacology.
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650 |
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4 |
|a Laboratory Medicine.
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650 |
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|a Human Genetics.
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650 |
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|a Pharmacology/Toxicology.
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700 |
1 |
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|a Gissberg, Olof.
|e editor.
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700 |
1 |
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|a Zain, Rula.
|e editor.
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700 |
1 |
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|a Lundin, Karin E.
|e editor.
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710 |
2 |
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|a SpringerLink (Online service)
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773 |
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|t Springer eBooks
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900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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