|
|
|
|
| LEADER |
03851nam a22003015i 4500 |
| 001 |
000290780 |
| 005 |
20210929105543.0 |
| 007 |
cr nn 008mamaa |
| 008 |
131107s2014 xxu| s |||| 0|eng d |
| 020 |
|
|
|a 9781627037426
|
| 024 |
7 |
|
|a 10.1007/978-1-62703-742-6
|2 doi
|
| 040 |
|
|
|a Sistema de Bibliotecas del Tecnológico de Costa Rica
|
| 245 |
1 |
0 |
|a Optimization in Drug Discovery :
|b In Vitro Methods /
|c edited by Gary W. Caldwell, Zhengyin Yan.
|
| 250 |
|
|
|a 2nd ed. 2014.
|
| 260 |
# |
# |
|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2014.
|
| 300 |
|
|
|a XVII, 597 p. 113 illus., 49 illus. in color. :
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a Methods in Pharmacology and Toxicology,
|
| 505 |
0 |
|
|a Small Molecule Formulation Screening Strategies in Drug Discovery -- Assessment of Drug Plasma Protein Binding in Drug Discovery -- Drug Partition in Red Blood Cells -- Permeability Assessment Using 5-Day Cultured Caco-2 Cell Monolayers -- In Situ Single Pass Perfused Rat Intestinal Model -- Metabolic Stability Assessed by Liver Microsomes and Hepatocytes -- Metabolic Assessment in Alamethicin-Activated Liver Microsomes: Co-Activating CYPs and UGTs -- Phenotyping UDP-Glucuronosyltransferases (UGTs) Involved in Human Drug Metabolism: An Update -- In Vitro CYP/FMO Reaction Phenotyping -- Human Pregnane X Receptor (hPXR) Activation Assay in Stable Cell Lines -- Characterization of Constitutive Androstane Receptor (CAR) Activation -- DNA Binding (Gel Retardation Assay) Analysis for Identification of Aryl Hydrocarbon (Ah) Receptor Agonists and Antagonists -- Cell-Based Assays for Identification of Aryl Hydrocarbon Receptor (AhR) Activators -- In Vitro CYP Induction Using Human Hepatocytes -- Assessment of CYP3A4 Time-Dependent Inhibition in Plated and Suspended Human Hepatocytes -- Evaluation of Time-Dependent CYP3A4 Inhibition Using Human Hepatocytes -- Rapidly Distinguishing Reversible and Time-Dependent CYP450 Inhibition Using Human Liver Microsomes, Co-Incubation, and Continuous Fluorometric Kinetic Analyses -- Identification of Time-Dependent CYP Inhibitors Using Human Liver Microsomes (HLM) -- CYP Time-Dependent Inhibition (TDI) Using an IC50 Shift Assay with Stable Isotopic Labeled Substrate Probes to Facilitate Liquid Chromatography/Mass Spectrometry Analyses -- Screening for P-Glycoprotein (Pgp) Substrates and Inhibitors -- In Vitro Characterization of Intestinal Transporter, Breast Cancer Resistance Protein (BCRP) -- In Vitro Characterization of Intestinal and Hepatic Transporters: MRP2 -- In Vitro Characterization of Hepatic Transporters OATP1B1 and OATP1B3 -- In Vitro Characterization of Renal Transporters OAT1, OAT3, and OCT2 -- General Guidelines for Setting Up an In Vitro LC/MS/MS Assay -- Metabolite Identification in Drug Discovery -- Drug, Lipid, and Acylcarnitine Profiling Using Dried Blood Spot (DBS) Technology in Drug Discovery -- In Vitro Trapping and Screening of Reactive Metabolites Using Liquid Chromatography-Mass Spectrometry -- Quantitative Assessment of Reactive Metabolites -- In Vitro Assessment of the Reactivity of Acyl Glucuronides -- In Vitro COMET Assay for Testing Genotoxicity of Chemicals -- Assessing DNA Damage Using a Reporter Gene System -- Improved AMES Test for Genotoxicity Assessment of Drugs: Preincubation Assay Using a Low Concentration of Dimethyl Sulfoxide -- Methods for Using the Mouse Lymphoma Assay to Screen for Chemical Mutagenicity and Photo-Mutagenicity.
|
| 650 |
|
0 |
|a Pharmacology.
|
| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
|
| 700 |
1 |
|
|a Caldwell, Gary W.
|e editor.
|
| 700 |
1 |
|
|a Yan, Zhengyin.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 900 |
|
|
|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|