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|a General introduction, Riekelt H. Houtkooper -- Biochemistry and Enzymology of Sirtuins, Yue Yang and Anthony A. Sauve -- NAD+ as a pharmacological tool to boost sirtuin activity, Riekelt H. Houtkooper -- Protein lysine acylation: abundance, dynamics and function, Olga Pougovkina and Vincent C. J. de Boer -- SIRT1 in metabolic health and disease, Marie Boutant and Carles Cantó -- Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function, Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey -- SIRT5 reveals novel enzymatic activities of sirtuins, Bin He and Hening Lin -- Diverse roles for SIRT6 in mammalian healthspan and longevity, Bernadette M. M. Zwaans, William Giblin and David B. Lombard -- Sirtuins in cancer – emerging role as modulators of metabolic reprogramming, Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis -- Sirtuins as metabolic modulators of muscle plasticity, Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx -- Sirtuins and aging, Carles Cantó and Riekelt Houtkooper -- Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk, Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi -- Sirtuin activation by small molecules, Hassina Massudi, Lindsay E. Wu, and David A. Sinclair -- Future perspective, Brian Kennedy -- Index.
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