Retinal Degenerative Diseases : Mechanisms and Experimental Therapy /
| Autor Corporativo: | |
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| Otros Autores: | , , , , , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Cham :
Springer International Publishing : Imprint: Springer,
2016.
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| Edición: | 1st ed. 2016. |
| Colección: | Advances in Experimental Medicine and Biology,
854 |
| Materias: |
Tabla de Contenidos:
- Part I Age-Related Macular Degeneration (AMD)
- Apolipoprotein E Isoforms and AMD
- Role of Chemokines in Shaping Macrophage Activity in AMD
- Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD)
- Gene Structure of the 10q26 locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?
- Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration
- Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration
- A Brief Discussion on Lipid Activated Nuclear Receptors and Their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD)
- Extracellular Matrix Alterations and Deposit Formation in AMD
- The NLRP3 Inflammasome and its Role in Age-related Macular Degeneration
- Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration
- Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease
- VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration
- Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration
- Gene-diet Interactions in Age-Related Macular Degeneration
- Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration
- Nanoceria: A Potential Therapeutic for Dry AMD
- β-amyloidopathy in the Pathogenesis of Age-Related Macular Degeneration in Correlation with Neurodegenerative Diseases
- Part II Macular Dystrophies/Inherited Macular Degeneration
- Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans
- Mouse Models of Stargardt 3 Dominant Macular Degeneration
- Current Progress in Deciphering Importance of VLC-PUFA in the Retina
- Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-related Macular Degeneration and Potential Therapies
- Part III Inherited Retinal Degenerations
- Hsp90 as a Potential Therapeutic Target in Retinal Disease
- Leber Congenital Amaurosis: Genotypes and Retinal Structure Phenotypes
- A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects
- Ablation of Chop Transiently Enhances Photoreceptor Survival But Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin
- Identification of a Novel Gene on 10q22 Causing Autosomal Dominant Retinitis Pigmentosa (adRP)
- FAM161A and TTC8 Are Differentially Expressed in Non-allelelic Early Onset Retinal Degeneration
- Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization
- RDS Functional Domains and Dysfunction in Disease
- TULP1 Missense Mutations Induces the Endoplasmic Reticulum Unfolded Protein Response Stress Complex (ER-UPR)
- Understanding Cone Photoreceptor Cell Death in Achromatopsia
- Geranylgeranylacetone Suppresses N-methyl-N-nitrosourea-induced Photoreceptor Cell Loss in Mice
- My Retina Tracker™: An On-line International Registry for People Affected with Inherited Orphan Retinal Degenerative Diseases and their Genetic Relatives – A New Resource
- A Mini-Review: Animal Models of GUCY2D Leber Congenital Amaurosis (LCA1)
- A Comprehensive Review of Mutations in the MERTK Proto-oncogene
- Part IV In Vivo Imaging and Other Diagnostic Advances
- New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo
- Reliability and repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia
- Quantitative Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is Not Increased in Non-Lesion Areas of Retina
- Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa
- Intra-familial Similarity of Wide-Field Fundus Autofluorescence in Inherited Retinal Dystrophy
- Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy.- The Development of a Cat Model of Retinal Detachment and Re-Attachment
- Part V Mechanisms of Degeneration
- The Role of X-Chromosome Inactivation in Retinal Development and Disease
- A Non-canonical Role for β-Secretase in the Retina
- The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors
- The Rate of Vitamin A Dimerization in Lipofuscinogenesis, Fundus Autofluorescence, Retinal Senescence and Degeneration
- Can Vitamin A be Improved to Prevent Blindness due to Age-Related Macular Degeneration, Stargardt Disease and Other Retinal Dystrophies?
- Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina
- Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets
- Neuronal Nitric Oxide Synthase as a Trigger of the N-methyl-N-nitrosourea-induced Photoreceptor Cell Death
- Molecular Principles for Decoding Homeostasis Disruptions in the Retinal Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases
- Aging and Vision
- Part VI Neuroprotection, Small Molecules & Related Therapeutic Approaches
- The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair
- Retinal Caveolin-1 Modulates Neuroprotective Signaling
- Photoreceptor Neuroprotection: Regulation of Akt activation through Serine/Threonine Phosphatases, PHLPP and PHLPPL
- The Role of AMPK pathway in Neuroprotection
- Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1
- Near-Infrared Photobiomodulation in Retinal Injury and Disease
- Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns
- Small Molecules that Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models
- Histone Deacetylase: Therapeutic Targets in Retinal Degeneration
- Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases
- Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury
- Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa
- Part VII Gene Therapy & Antisense.- Gene Therapy for MERTK-Associated Retinal Degenerations
- Tamoxifen-containing Eye Drops Successfully Trigger Cre-mediated Recombination in the Entire Eye
- Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages
- Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin
- Antisense Oligonucleotide Therapy for Inherited Retinal Dystrophies
- Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins
- Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes
- Part VIII Stem Cells & Cell-based Therapies
- Regenerative Medicine: Solution in Sight
- Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-derived Retinal Pigment Epithelium Cells
- Human Retinal Pigment Epithelium Stem Cell (RPESC)
- Embryonic Stem Cell‐Derived Microvesicles: Could They Be Used for Retinal Regeneration?
- Intravitreal Implantation of Genetically Modified Autologous Bone Marrow-Derived Stem Cells for Treating Retinal Disorders.- Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina
- Interkinetic Nuclear Migration in the Regenerating Retina
- Part IX Photoreceptors & Inner Retina
- Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules
- A Novel Approach to Identify Photoreceptor Compartment-Specific Tulp1 Binding Partners
- Thyroid Hormone Signaling and Cone Photoreceptor Viability
- In-Depth Functional Diagnostics of
- Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination
- The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium
- Regulation of Retinal Development Via the Epigenetic Modification of Histone
- The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis
- Identification of Tyrosine O Sulfated Proteins in Cow Retina and the 661W Cell Line
- The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.-Characterization of Antibodies to Identify Cellular Expression of Dopamine
- Receptor 4
- A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina
- JNK Inhibition Reduced Retinal Ganglion Cell Death After Ischemia/Reperfusion In Vivo and After Hypoxia In Vitro
- Cell Fate of Müller Cells During Photoreceptor Regeneration in an MNU-induced Retinal Degeneration Model of Zebrafish
- Polymodal Sensory Integration in Retinal Ganglion Cells
- Pigment Epithelium-derived Factor, a Protective Factor for Photoreceptors In Vivo
- Part X Retinal Pigment Epithelium (RPE)
- The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells
- Live Imaging of LysoTracker-Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex Vivo
- Cre Recombinase: You Can’t Live with It, and You Can’t Live without It
- Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells
- Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: maxiK, Cav1.3 and Bestrophin-1
- Lysosomal Trafficking Regulator (LYST)
- Live-cell Imaging of Phagosome Motility in Primary Mouse RPE Cells
- RPE Cell and Sheet Properties in Normal and Diseased Eyes
- Valproic Acid Induced Human Retinal Pigment Epithelial Cell Death as Well as its Survival Aft.