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02676nam a22003375i 4500 |
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978-0-387-44961-6 |
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20191027171351.0 |
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cr nn 008mamaa |
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100301s2006 xxu| s |||| 0|eng d |
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|a 9780387449616
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| 024 |
7 |
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|a 10.1007/978-0-387-44961-6
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Optimizing the "Drug-Like" Properties of Leads in Drug Discovery
|c edited by Ronald Borchardt, Edward Kerns, Michael Hageman, Dhrien Thakker, James Stevens.
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| 250 |
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|a 1st ed. 2006.
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| 260 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2006.
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| 300 |
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|a X, 512 p. 190 illus., 39 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Biotechnology: Pharmaceutical Aspects ;
|v IV
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| 505 |
0 |
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|a Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds -- Role of Mechanistic Transport Studies in Lead Optimization -- Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions -- Case History — Use of ADME Studies for Optimization of Drug Candidates -- Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization -- Lipid-based Systems, Drug Exposure and Lead Optimization -- Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure -- Application of Physicochemical Data to Support Lead Optimization by Discovery Teams -- Computational Models Supporting Lead Optimization in Drug Discovery -- Prodrug Strategies for Improving Drug-Like Properties -- The Application of Multivariate Data Analysis to Compound Property Optimization -- Case History: Toxicology Biomarker Development Using Toxicogenomics -- Predicting Idiosyncratic Drug Reactions -- Elementary Predictive Toxicology for Advanced Applications -- The Application of PK/PD Modeling and Simulations During Lead Optimization -- Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization -- Optimizing Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development -- The Relevance of Transporters in Determining Drug Disposition.
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| 650 |
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|a Pharmacology.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 700 |
1 |
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|a Borchardt, Ronald.
|e editor.
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| 700 |
1 |
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|a Kerns, Edward.
|e editor.
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| 700 |
1 |
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|a Hageman, Michael.
|e editor.
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| 700 |
1 |
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|a Thakker, Dhrien.
|e editor.
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| 700 |
1 |
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|a Stevens, James.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 856 |
4 |
0 |
|u https://doi.org/10.1007/978-0-387-44961-6
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