Optimizing the "Drug-Like" Properties of Leads in Drug Discovery

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Borchardt, Ronald. (Editor), Kerns, Edward. (Editor), Hageman, Michael. (Editor), Thakker, Dhrien. (Editor), Stevens, James. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2006.
Edition:1st ed. 2006.
Series:Biotechnology: Pharmaceutical Aspects ; IV
Subjects:
Online Access:https://doi.org/10.1007/978-0-387-44961-6
Table of Contents:
  • Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds
  • Role of Mechanistic Transport Studies in Lead Optimization
  • Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions
  • Case History - Use of ADME Studies for Optimization of Drug Candidates
  • Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization
  • Lipid-based Systems, Drug Exposure and Lead Optimization
  • Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure
  • Application of Physicochemical Data to Support Lead Optimization by Discovery Teams
  • Computational Models Supporting Lead Optimization in Drug Discovery
  • Prodrug Strategies for Improving Drug-Like Properties
  • The Application of Multivariate Data Analysis to Compound Property Optimization
  • Case History: Toxicology Biomarker Development Using Toxicogenomics
  • Predicting Idiosyncratic Drug Reactions
  • Elementary Predictive Toxicology for Advanced Applications
  • The Application of PK/PD Modeling and Simulations During Lead Optimization
  • Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization
  • Optimizing Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development
  • The Relevance of Transporters in Determining Drug Disposition.