Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards

Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards

Detalles Bibliográficos
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Khera, K.S. (Editor ), Grice, H.C. (Editor ), Clegg, D.J. (Editor )
Formato: eBook
Lenguaje:English
Publicado: New York, NY : Springer New York : Imprint: Springer, 1989.
Edición:1st ed. 1989.
Colección:Current Issues in Toxicology,
Materias:
Pharmacology.
Cell biology.
Anthropology.
Pharmacy.
Pharmacology/Toxicology.
Cell Biology.
Acceso en línea:https://doi.org/10.1007/978-1-4684-6379-8
LEADER 03362nam a22003855i 4500
001 978-1-4684-6379-8
005 20191024162206.0
007 cr nn 008mamaa
008 121227s1989 xxu| s |||| 0|eng d
020 |a 9781468463798 
024 7 |a 10.1007/978-1-4684-6379-8  |2 doi 
040 |a Sistema de Bibliotecas del Tecnológico de Costa Rica 
245 1 0 |a Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards  |c edited by K.S. Khera, H.C. Grice, D.J. Clegg. 
250 |a 1st ed. 1989. 
260 # # |a New York, NY :  |b Springer New York :  |b Imprint: Springer,  |c 1989. 
300 |a XII, 133 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Current Issues in Toxicology, 
505 0 |a I. Introduction -- II. Terminology and Definitions -- References -- III. Teratogenicity (Embryotoxicity) Studies: Design, Conduct, and Evaluation -- 3.1. Introduction -- 3.2. Protocol -- 3.3. Conduct of the Study -- 3.4. Evaluation of Animal Data -- References -- IV. Multigeneration Studies -- 4.1. Introduction -- 4.2. Test Protocols -- 4.3. Test Material -- 4.4. Test Species -- 4.5. Route of Administration -- 4.6. Method of Administration -- 4.7. Dose Levels -- 4.8. Performance of Multigeneration Studies -- 4.9. Evaluation of Animal Data -- References -- V. Behavioral-Functional Teratology -- 5.1. Introduction -- 5.2. Review Articles -- 5.3. Methods Currently in Use or Under Development -- 5.4. Current Status of Testing Procedures and Use -- 5.4.3.1. Food and Drug Administration -- 5.4.3.2. Environmental Protection Agency -- 5.5. Discussion -- References -- VI. In Vitro Developmental Toxicity Assays -- 6.1. Introduction -- 6.2. Assay Systems Using Submammalian Species -- 6.3. Assay Systems Using Mammalian Species -- 6.4. Role of In Vitro Assays for Teratogenicity -- References -- VII. Statistical Methods for Developmental Toxicity Studies -- 7.1. Introduction -- 7.2. Comparison Between Exposed and Unexposed Groups -- 7.3. Dose-Response Models -- 7 4 Summary and Conclusions -- References -- VIII. Epidemiology -- 8.1. Introduction -- 8.2. The Conduct of Epidemiologic Studies on Human Reproduction -- 8.3. Descriptive Studies -- 8.4. Etiologic Studies -- 8.5. Characteristics of an Acceptable Human Reproduction Study -- References -- IX. Extrapolation of Reproductive Risks from Animal and Human Data -- 9.1. Introduction -- 9.2. Classification of Chemicals for In Utero Effects -- 9.3. Methods of Risk Extrapolation -- References -- X. Guidelines for Reproductive Toxicity Tests in Different Countries With a Proposal for International Harmonization -- 10.1. Introduction -- 10.2. Current Guidelines for Reproductive Toxicity Testing -- 10.3. Harmonization of Guidelines -- 10.4. Steps Toward Harmonization -- 10.5. Conclusions -- References. 
650 0 |a Pharmacology. 
650 0 |a Cell biology. 
650 0 |a Anthropology. 
650 0 |a Pharmacy. 
650 1 4 |a Pharmacology/Toxicology. 
650 2 4 |a Cell Biology. 
650 2 4 |a Anthropology. 
650 2 4 |a Pharmacy. 
700 1 |a Khera, K.S.  |e editor. 
700 1 |a Grice, H.C.  |e editor. 
700 1 |a Clegg, D.J.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
856 4 0 |u https://doi.org/10.1007/978-1-4684-6379-8 

Ejemplares similares