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02429nam a22002895i 4500 |
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978-1-4939-3609-0 |
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20191023112113.0 |
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cr nn 008mamaa |
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160616s2016 xxu| s |||| 0|eng d |
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|a 9781493936090
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|a 10.1007/978-1-4939-3609-0
|2 doi
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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|a In Silico Methods for Predicting Drug Toxicity
|c edited by Emilio Benfenati.
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| 250 |
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|a 1st ed. 2016.
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| 260 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2016.
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| 300 |
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|a XI, 534 p. 193 illus., 156 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Methods in Molecular Biology,
|v 1425
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|a QSAR Methods -- In Silico 3D-Modelling of Binding Activities -- Modeling Pharmacokinetics -- Modeling ADMET -- In Silico Prediction of Chemically-Induced Mutagenicity: How to Use QSAR Models and Interpret Their Results -- In Silico Methods for Carcinogenicity Assessment -- VirtualToxLab: Exploring the Toxic Potential of Rejuvenating Substances Found in Traditional Medicines -- In Silico Model for Developmental Toxicity: How to Use QSAR Models and Interpret Their Results -- In Silico Models for Repeated Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs -- In Silico Models for Acute Systemic Toxicity -- In Silico Models for Hepatotoxicity -- In Silico Models for Ecotoxicity of Pharmaceuticals -- Use of Read-Across Tools -- Adverse Outcome Pathways as Tools to Assess Drug-Induced Toxicity -- A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure -- In Silico Study of In Vitro GPCR Assays by QSAR Modeling -- Taking Advantage of Databases -- QSAR Models at the United States FDA/NCTR -- A Round Trip from Medicinal Chemistry to Predictive Toxicology -- The Use of In Silico Models Within a Large Pharmaceutical Company -- The Consultancy Activity on In Silico Models for Genotoxic Prediction of Pharmaceutical Impurities.
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| 650 |
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|a Pharmacology.
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| 650 |
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|a Pharmacology/Toxicology.
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| 700 |
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|a Benfenati, Emilio.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 856 |
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|u https://doi.org/10.1007/978-1-4939-3609-0
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