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04960nam a22003375i 4500 |
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978-3-642-78458-3 |
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20191023121740.0 |
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cr nn 008mamaa |
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121227s1994 gw | s |||| 0|eng d |
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|a 9783642784583
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|a 10.1007/978-3-642-78458-3
|2 doi
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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|a Regulation of Gene Expression and Brain Function
|c edited by Paul J. Harrison.
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| 250 |
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|a 1st ed. 1994.
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| 260 |
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|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 1994.
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| 300 |
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|a X, 64 p. 10 illus.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Basic and Clinical Aspects of Neuroscience,
|v 6
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|a Introduction: Gene Expression in the Brain -- References -- Brain Gene Expression in Development and After Injury -- Hybridization Complexity Studies of Messenger RNAs -- Recombinant DNA Technology -- Probes for mRNAs, Genes and Proteins -- Cellular Localization of mRNAs and Proteins in Brain -- Analysis of the Regulation and Function of Specific Genes -- Cloning and Characterization of Known Brain-Specific Genes -- Neurotransmitter Enzymes -- Multigene Families Encoding Receptors -- Glia-Specific Genes -- Screening cDNA Libraries for Brain-Specific Genes -- Identification of Other Developmentally Regulated Genes -- Genes That Are Turned On During Development -- Genes That Are Turned Off During Development -- Subcellular Targeting of mRNAs and Proteins -- Neurotrophic Factors, Brain Injury and Disease -- References -- Sorting and Intracellular Transport of RNA in Neurons: Regulation of Gene Expression at Synaptic Sites -- Protein Synthesis in Neurons: A Distributed Network -- Differential Distribution of RNA Species Within Neurons -- Identifying Other mRNAs That Are Present in Dendrites -- Biochemical Studies of the Proteins Synthesized Within Dendrites -- Approaches to Isolate and Identify Dendritic mRNAs -- How Could the Differential Distribution of RNA be Generated? -- Local Regulation of Transcription in Multinucleated Cells -- Domain-Specific Stabilization or Degradation -- mRNA Sorting -- mRNA Sorting Based on Signals in the RNA Itself -- Sorting Based on Signals in the Nascent Polypeptide -- RNA Sorting in Neurons -- Dendritic Transport of RNA -- Translational Repression of Transported mRNAs -- Docking at Synaptic Sites -- Dendritic RNAs That Do Not Encode Proteins -- mRNA in Axons -- Sorting of mRNA in Other Differentiated Cell Types -- Why Are Some Proteins Synthesized Locally? -- Conclusion -- References -- Chromatin Structure, Gene Expression, and Nuclear Aluminum in Alzheimer's Disease -- Gene Expression in Eukaryotic Cells -- Basic Structures of Eukaryotic Chromatin: DNA Compaction -- Organization of the Genetic Material in the Neuronal Nucleus -- RNA Generation in the Neuronal Nucleus -- Activator and Repressor Interactions with the Upstream Regions of Genes -- Competition Between Activator and Repressor Proteins at the Transcription Start Regions of Genes -- Changes in Chromatin Structure and Gene Expression in AD -- Selective Messenger RNA Reduction in AD -- Probing of HNF-L Neuronal Chromatin Structure Employing MN and the Restriction Endonuclease AvaI -- Occlusion of the HNF-L Locus in AD Neocortex -- Repression of the Single-Copy HNF-L Gene - A Contributing Factor to AD Pathogenesis? -- The Neuropathologic Changes in AD: Senile Plaques and Neurofibrillary Tangles -- Aluminum in the Nuclear Compartment: Effects on Chromatin Structure and Gene Expression -- Biologic Effects and Neurotoxicity -- Cytotoxic and Genotoxic Effects -- Interaction with DNA and Nuclear Processes -- Aluminum and Nuclear Processes -- Localization of Aluminum in Experimental Aluminum Encephalopathy, Neurodegenerative Disease, and AD -- Aluminum Binding and Interactions Between H1 Linker Protein and DNA -- Selective Genetic Vulnerability of Neurons in AD -- Conclusions -- References -- Expression of the ?-Amyloid Precursor Protein Gene and the Pathogenesis of Alzheimer's Disease -- Brain Gene Expression and the Role of Messenger RNA -- The ?-Amyloid Precursor Protein and Alzheimer's Disease -- Brain APP Messenger RNA in Alzheimer's Disease -- Brain APP mRNA in Experimental Injury and Manipulation -- Messenger RNA and the Metabolic Health of Neurons in Alzheimer's Disease -- Conclusions -- References -- Gene Expression in Down's Syndrome, Parkinson's Disease, and Schizophrenia -- Down's Syndrome -- Parkinson's Disease -- Schizophrenia -- References.
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| 650 |
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|a Biochemistry.
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| 650 |
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|a Neurosciences.
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| 650 |
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|a Neurology .
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| 650 |
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|a Biochemistry, general.
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| 650 |
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|a Neurosciences.
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| 650 |
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|a Neurology.
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| 700 |
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|a Harrison, Paul J.
|e editor.
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| 710 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 856 |
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|u https://doi.org/10.1007/978-3-642-78458-3
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