Regulation of Gene Expression and Brain Function
| Corporate Author: | |
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| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
1994.
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| Edition: | 1st ed. 1994. |
| Series: | Basic and Clinical Aspects of Neuroscience,
6 |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-3-642-78458-3 |
Table of Contents:
- Introduction: Gene Expression in the Brain
- References
- Brain Gene Expression in Development and After Injury
- Hybridization Complexity Studies of Messenger RNAs
- Recombinant DNA Technology
- Probes for mRNAs, Genes and Proteins
- Cellular Localization of mRNAs and Proteins in Brain
- Analysis of the Regulation and Function of Specific Genes
- Cloning and Characterization of Known Brain-Specific Genes
- Neurotransmitter Enzymes
- Multigene Families Encoding Receptors
- Glia-Specific Genes
- Screening cDNA Libraries for Brain-Specific Genes
- Identification of Other Developmentally Regulated Genes
- Genes That Are Turned On During Development
- Genes That Are Turned Off During Development
- Subcellular Targeting of mRNAs and Proteins
- Neurotrophic Factors, Brain Injury and Disease
- References
- Sorting and Intracellular Transport of RNA in Neurons: Regulation of Gene Expression at Synaptic Sites
- Protein Synthesis in Neurons: A Distributed Network
- Differential Distribution of RNA Species Within Neurons
- Identifying Other mRNAs That Are Present in Dendrites
- Biochemical Studies of the Proteins Synthesized Within Dendrites
- Approaches to Isolate and Identify Dendritic mRNAs
- How Could the Differential Distribution of RNA be Generated?
- Local Regulation of Transcription in Multinucleated Cells
- Domain-Specific Stabilization or Degradation
- mRNA Sorting
- mRNA Sorting Based on Signals in the RNA Itself
- Sorting Based on Signals in the Nascent Polypeptide
- RNA Sorting in Neurons
- Dendritic Transport of RNA
- Translational Repression of Transported mRNAs
- Docking at Synaptic Sites
- Dendritic RNAs That Do Not Encode Proteins
- mRNA in Axons
- Sorting of mRNA in Other Differentiated Cell Types
- Why Are Some Proteins Synthesized Locally?
- Conclusion
- References
- Chromatin Structure, Gene Expression, and Nuclear Aluminum in Alzheimer's Disease
- Gene Expression in Eukaryotic Cells
- Basic Structures of Eukaryotic Chromatin: DNA Compaction
- Organization of the Genetic Material in the Neuronal Nucleus
- RNA Generation in the Neuronal Nucleus
- Activator and Repressor Interactions with the Upstream Regions of Genes
- Competition Between Activator and Repressor Proteins at the Transcription Start Regions of Genes
- Changes in Chromatin Structure and Gene Expression in AD
- Selective Messenger RNA Reduction in AD
- Probing of HNF-L Neuronal Chromatin Structure Employing MN and the Restriction Endonuclease AvaI
- Occlusion of the HNF-L Locus in AD Neocortex
- Repression of the Single-Copy HNF-L Gene - A Contributing Factor to AD Pathogenesis?
- The Neuropathologic Changes in AD: Senile Plaques and Neurofibrillary Tangles
- Aluminum in the Nuclear Compartment: Effects on Chromatin Structure and Gene Expression
- Biologic Effects and Neurotoxicity
- Cytotoxic and Genotoxic Effects
- Interaction with DNA and Nuclear Processes
- Aluminum and Nuclear Processes
- Localization of Aluminum in Experimental Aluminum Encephalopathy, Neurodegenerative Disease, and AD
- Aluminum Binding and Interactions Between H1 Linker Protein and DNA
- Selective Genetic Vulnerability of Neurons in AD
- Conclusions
- References
- Expression of the ?-Amyloid Precursor Protein Gene and the Pathogenesis of Alzheimer's Disease
- Brain Gene Expression and the Role of Messenger RNA
- The ?-Amyloid Precursor Protein and Alzheimer's Disease
- Brain APP Messenger RNA in Alzheimer's Disease
- Brain APP mRNA in Experimental Injury and Manipulation
- Messenger RNA and the Metabolic Health of Neurons in Alzheimer's Disease
- Conclusions
- References
- Gene Expression in Down's Syndrome, Parkinson's Disease, and Schizophrenia
- Down's Syndrome
- Parkinson's Disease
- Schizophrenia
- References.