DNA-Protein Interactions

DNA-Protein Interactions

Bibliographic Details
Main Author: Travers, A. (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Dordrecht : Springer Netherlands : Imprint: Springer, 1993.
Edition:1st ed. 1993.
Subjects:
Animal anatomy.
Human genetics.
Animal Anatomy / Morphology / Histology.
Human Genetics.
Online Access:https://doi.org/10.1007/978-94-011-1480-6
Table of Contents:
  • 1 DNA structure
  • 1.1 Structural features of DNA
  • 1.2 DNA polymorphism
  • 1.3 Conformational variability of DNA
  • 1.4 Intrinsic bending of DNA
  • 1.5 DNA supercoiling and topology
  • 1.6 The topology of protein-bound DNA
  • 1.7 Structure of supercoiled DNA
  • References
  • 2 DNA-protein interactions: The three-dimensional architecture of DNA-protein complexes
  • 2.1 General principles
  • 2.2 Local DNA conformation and protein binding
  • 2.3 DNA wrapping
  • 2.4 DNA configuration and sequence periodicity
  • 2.5 The establishment of DNA architecture
  • References
  • 3 DNA-protein interactions: Sequence specific recognition
  • 3.1 General principles of sequence specific recognition
  • 3.2 Structural motifs for sequence specific binding
  • 3.3 Co-operative binding to DNA
  • 3.4 Co-operativity at a distance: DNA looping
  • 3.5 Protein flexibility in DNA-protein complexes
  • References
  • 4 The mechanism of RNA chain initiation
  • 4.1 The promoter
  • 4.2 RNA polymerases
  • 4.3 The kinetics of transcription initiation
  • 4.4 The molecular interactions of RNA polymerase with a promoter site
  • 4.5 The topological consequences of transcription
  • 4.6 Transcriptional activators
  • 4.7 Transcriptional activation by negative superhelicity
  • 4.8 How does RNA polymerase melt promoter DNA?
  • References
  • 5 The regulation of promoter selectivity in eubacteria
  • 5.1 Control of stable RNA synthesis
  • 5.2 Stable RNA promoters
  • 5.3 The transition from exponential growth to stationary phase and vice versa
  • 5.4 Sigma factors and promoter recognition
  • 5.5 The heat shock response
  • 5.6 ?54: A target for transcriptional enhancers
  • 5.7 The transcriptional programmes of bacterial viruses
  • References
  • 6 The mechanism of eukaryotic transcription
  • 6.1 Eukaryotic transcriptional regulatory elements
  • 6.2 Eukaryotic transcriptional regulators: structure
  • 6.3 Specificity and selectivity of eukaryotic transcription factors
  • 6.4 Sp1 transcription factor
  • 6.5 Heat shock transcription factor (HSF)
  • 6.6 How do transcriptional activators work?
  • 6.7 Transcription by RNA polymerase III
  • 6.8 The establishment of repression
  • References
  • 7 Chromatin and transcription
  • 7.1 Local control of chromatin structure
  • 7.2 The structural organization of chromatin
  • 7.2.1 Chromosomal superstructure
  • 7.3 Heterochromatin
  • 7.4 The regulation of transcriptional competence
  • References.

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