Rang & Dale's pharmacology /
| Main Author: | |
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| Other Authors: | , |
| Format: | Book |
| Language: | English |
| Published: |
London :
Elsevier Ltd.,
©2024
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| Edition: | Tenth edition |
| Subjects: |
Table of Contents:
- General principles. What is pharmacology?.How drugs act: general principles. How drugs act: molecular aspects. How drugs act: cellular aspects - excitation, contraction and secretion. How drugs act: biopharmaceuticals and gene therapy. Cell proliferation, apoptosis, repair and regeneration. Cellular mechanisms: host defence. Method and measurement in pharmacology. Absorption and distribution of drugs. Drug metabolism and elimination. Pharmacokinetics. Individual variation, pharmacogenomics and personalised medicine.
- Chemical mediators. Chemical mediators and the autonomic nervous system. Cholinergic transmission. Noradrenergic transmission. 5-Hydroxytryptamine and purines. Local hormones: histamine, lipids, peptides and proteins. Cannabinoids. Nitric oxide and related mediators.
- Drugs affecting major organ systems. The heart. The vascular system. Atherosclerosis and lipoprotein metabolism. Haemostasis and thrombosis. Haemopoietic system and treatment of anaemia. Skin. Eye. Respiratory system. The kidney and urinary system. The gastrointestinal tract. The control of blood glucose and drug treatment of diabetes mellitus. Obesity. The pituitary and the adrenal cortex. Thyroid. The reproductive system. Bone metabolism.
- Nervous system. Chemical.transmission and drug action in the central nervous system. Amino acid transmitters. Other transmitters and modulators. Neurodegenerative diseases. General anaesthetic agents. Headache. Analgesic drugs. Local anaesthetics and other drugs affecting sodium channels. Anxiolytic and hypnotic drugs. Antiepileptic drugs. Antipsychotic drugs. Antidepressant drugs. Psychoactive drugs. Drug use and addiction.
- Drugs used for the treatment of infections and cancer. Basic principles of antimicrobial chemotherapy. Antibacterial drugs. Antiviral drugs. Antifungal drugs. Antiprotozoal drugs. Antihelminthic drugs. Anticancer drugs.
- Special topics. Harmful effects of drugs. Lifestyle drugs and drugs in sport. Drug discovery and development.