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02748nam a22003735i 4500 |
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20210617094628.0 |
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150420s2015 gw | s |||| 0|eng d |
| 020 |
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|a 9783319168500
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| 024 |
7 |
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|a 10.1007/978-3-319-16850-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 100 |
1 |
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|a Fernández Stigliano, Ariel.
|e author.
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| 245 |
1 |
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|a Biomolecular Interfaces :
|b Interactions, Functions and Drug Design /
|c by Ariel Fernández Stigliano.
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| 250 |
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|a 1st ed. 2015.
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| 260 |
# |
# |
|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2015.
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| 300 |
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|a XIX, 372 p. 145 illus., 86 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 505 |
0 |
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|a The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems.
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| 650 |
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|a Proteins .
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| 650 |
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|a Cell membranes .
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| 650 |
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|a Molecular biology.
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| 650 |
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|a Pharmaceutical technology.
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| 650 |
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|a Biophysics.
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| 650 |
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|a Biological physics.
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| 650 |
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4 |
|a Protein-Ligand Interactions.
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| 650 |
2 |
4 |
|a Membrane Biology.
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| 650 |
2 |
4 |
|a Molecular Medicine.
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| 650 |
2 |
4 |
|a Pharmaceutical Sciences/Technology.
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| 650 |
2 |
4 |
|a Biological and Medical Physics, Biophysics.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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