Drug Metabolism : Current Concepts /
| Autor Corporativo: | |
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| Otros Autores: | , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2005.
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| Edición: | 1st ed. 2005. |
| Materias: |
Tabla de Contenidos:
- Drug Metabolism In Context: Introduction
- Absorption
- Drug Distribution
- Dynamics Of Drug Action
- Drug Clearance
- Dynamics Of Drug Clearance
- Pathways Of Biotransformation – Phase I Reactions: Introduction
- Phase I And Phase Ii Metabolism: General Considerations
- Oxidations Involving The Microsomal Mixed-Function Oxidase System
- Oxidations Involving Other Enzymatic Systems
- Metabolic Reactions Involving Reduction
- Hydrolysis
- Miscellanous Phase I Reactions
- The Fate Of Phase I Reaction Products
- . Pathways Of Biotransformation – Phase I Reactions: Introduction
- Glucuronidation
- Acetylation
- Glutathione Conjugation
- Other Conjugative Reactions
- Concluding Remarks
- Enzymatic Systems Involved In Drug Biotransformation: Ntroduction
- Interaction Between A Drug Substrate And An Enzyme
- Enzyme Systems With Specific Roles
- Final Remarks
- Induction And Inhibition Of Drug-Metabolising Enzymes
- Introduction
- Induction
- Inhibition
- Consequences Of The Above Phenomena
- Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition
- Factors That Influence Drug Biotransformation
- Introduction
- Intrinsic Factors
- Environmental Factors
- Further Observations
- Impact Of Gene Variability On Drug Metabolism
- Introduction
- Basic Principles Of Pharmacogenetics
- Pharmaco-Informatics
- Implications For Third Millennium Medicine
- Drug Interactions And Adverse Reactions: Introduction
- Drug-Drug Interactions
- Interactions Between Drugs And Other Entities
- Adverse Reactions
- Summary
- Strategies For Drug Design
- Introduction
- Pharmacokinetics And Metabolism In Drug Research
- The Role Of Formulation
- Concluding Remarks
- Index.