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02686nam a22003015i 4500 |
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20210903121018.0 |
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cr nn 008mamaa |
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150810s2015 xxu| s |||| 0|eng d |
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|a 9781493929146
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| 024 |
7 |
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|a 10.1007/978-1-4939-2914-6
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a G Protein-Coupled Receptors in Drug Discovery :
|b Methods and Protocols /
|c edited by Marta Filizola.
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| 250 |
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|a 2nd ed. 2015.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2015.
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| 300 |
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|a XII, 327 p. 71 illus., 50 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Methods in Molecular Biology,
|v 1335
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| 505 |
0 |
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|a Purification of Stabilized GPCRs for Structural and Biophysical Analyses -- Purification and Crystallization of a Thermostabilized Agonist-Bound Conformation of the Human Adenosine A2A Receptor -- 2D Projection Analysis of GPCR Complexes by Negative Stain Electron Microscopy -- Nuts and Bolts of CF3 and CH3 NMR Towards the Understanding of Conformational Exchange of GPCRs -- Single-Molecule Fluorescence Microscopy for the Analysis of Fast Receptor Dynamics -- Quantitative Multi-Color Detection Strategies for Bioorthogonally-Labeled GPCRs -- Approaches to Characterize and Quantify Oligomerization of GPCRs -- Monitoring G Protein Activation in Cells with BRET -- Use of Fluorescence Indicators in Receptor Ligands -- Detection and Quantification of Intracellular Signalling Using FRET-Based Biosensors and High Content Imaging -- The Measurement of Receptor Signaling Bias -- Approaches to Assess Functional Selectivity in GPCRs: Evaluating G Protein Signaling in an Endogenous Environment -- Bioluminescence Resonance Energy Transfer Approaches to Discover Bias in GPCR Signaling -- Virus-Mediated Expression of DREADDs for In Vivo Metabolic Studies -- High-Throughput Screening for Allosteric Modulators of GPCRs -- Radioligand Binding Assay for an Exon 11-Associated Mu Opioid Receptor Target -- Docking and Virtual Screening Strategies for GPCR Drug Discovery -- The Dynamic Process of Drug-GPCR Binding at either Orthosteric or Allosteric Sites Evaluated by Metadynamics -- Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs -- Interaction Fingerprints and Their Applications to Identify Hot Spots.
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| 650 |
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|a Pharmacology.
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| 650 |
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0 |
|a Proteomics.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 650 |
2 |
4 |
|a Proteomics.
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| 700 |
1 |
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|a Filizola, Marta.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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