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02905nam a22003375i 4500 |
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20210414130536.0 |
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cr nn 008mamaa |
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110413s2010 xxu| s |||| 0|eng d |
| 020 |
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|a 9780387766430
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| 024 |
7 |
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|a 10.1007/978-0-387-76643-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Current Trends in Monoclonal Antibody Development and Manufacturing /
|c edited by Steven J. Shire, Wayne Gombotz, Karoline Bechtold-Peters, James Andya.
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| 250 |
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|a 1st ed. 2010.
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| 260 |
# |
# |
|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2010.
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| 300 |
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|a XIV, 354 p. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Biotechnology: Pharmaceutical Aspects ;
|v XI
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| 505 |
0 |
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|a Design Of Therapeutic MABS -- CDR Repair: A Novel Approach to Antibody Humanization -- Nanobodies, Single-Domain Antigen-Binding Fragments of Camelid Heavy-Chain Antibodies -- Expression and Production of MABS -- GPEx® A Flexible Method for the Rapid Generation of Stable, High Expressing, Antibody Producing Mammalian Cell Lines -- Advancing Our Cell Culture Platform: Incorporating Lessons Learned and New Technologies -- Recovery and Purification -- Addressing Changes Associated with Technology Transfer: A Case Study -- Concepts for Disposables in Biopharmaceutical Manufacture -- Formulation and Delivery -- Formulation and Delivery Issues for Monoclonal Antibody Therapeutics -- Challenges in the Development of High Protein Concentration Formulations -- Protein Immobilization by Crystallization and Precipitation: An Alternative to Lyophilization -- Analytics and Specification Setting for MABS -- Characterizing High Affinity Antigen/Antibody Complexes by Kinetic and Equilibrium Based Methods -- Analytical Characterization of Monoclonal Antibodies: Linking Structure to Function -- Analysis of Irreversible Aggregation, Reversible Self-association and Fragmentation of Monoclonal Antibodies by Analytical Ultracentrifugation -- Biophysical Signatures of Monoclonal Antibodies -- Pharmacokinetics and Immunogenicity -- Impact of Fc Glycosylation on Monoclonal Antibody Effector Functions and Degradation by Proteases -- Immunogenicity Assessment of Antibody Therapeutics -- Armed Antibodies and New Classes of Antibodies -- Production of Monoclonal Antibodies in E. coli -- Recent Advancements in the Use of Antibody Drug Conjugates for Cancer Therapy -- Antibody Radiolabeling.
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| 650 |
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0 |
|a Neurosciences.
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| 650 |
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0 |
|a Pharmacology.
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| 650 |
1 |
4 |
|a Neurosciences.
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| 650 |
2 |
4 |
|a Pharmacology/Toxicology.
|
| 700 |
1 |
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|a Shire, Steven J.
|e editor.
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| 700 |
1 |
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|a Gombotz, Wayne.
|e editor.
|
| 700 |
1 |
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|a Bechtold-Peters, Karoline.
|e editor.
|
| 700 |
1 |
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|a Andya, James.
|e editor.
|
| 710 |
2 |
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|a SpringerLink (Online service)
|
| 773 |
0 |
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|t Springer eBooks
|