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02864nam a22003015i 4500 |
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20210429090200.0 |
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cr nn 008mamaa |
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101029s2011 xxu| s |||| 0|eng d |
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|a 9781607618492
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| 024 |
7 |
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|a 10.1007/978-1-60761-849-2
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Drug Safety Evaluation :
|b Methods and Protocols /
|c edited by Jean-Charles Gautier.
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| 250 |
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|a 1st ed. 2011.
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| 260 |
# |
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|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2011.
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| 300 |
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|a XIII, 431 p. 78 illus., 4 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 691
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| 505 |
0 |
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|a Developing Combination Drugs in Preclinical Studies -- Preclinical Evaluation of Juvenile Toxicity -- Necropsy and Sampling Procedures in Rodents -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation -- Principles and Methods of Immunohistochemistry -- Tissue Microarrays and Digital Image Analysis -- Micronucleus Assay and Labeling of Centromeres with FISH Technique -- The Use of Bacterial Repair Endonucleases in the Comet Assay -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel -- Generation and Analysis of Transcriptomics Data -- Protocols of Two-Dimensional Difference Gel Electrophoresis (2D-DIGE) to Investigate Mechanisms of Toxicity -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR -- Statistical Analysis of Quantitative RT-PCR Results -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes -- FETAX Assay for Evaluation of Developmental Toxicity -- Evaluation of Embryotoxicity Using the Zebrafish Model -- Protocols of In vitro Protein Covalent Binding Studies in Liver -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In vitro -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In vitro -- 1-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine -- Identification of Chemical Adducted Proteins in Urine by Multi-Dimensional Protein Identification Technology (LC/LC-MS/MS) -- Optimization of SELDI for Biomarker Detection in Plasma -- Differential Proteomics Incorporating iTRAQ Labelling and Multi-Dimensional Separations -- NMR and MS Methods for Metabonomics -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring.
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| 650 |
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0 |
|a Toxicology.
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| 650 |
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0 |
|a Medical laboratories.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 650 |
2 |
4 |
|a Laboratory Medicine.
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| 700 |
1 |
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|a Gautier, Jean-Charles.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
|