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131025s2014 ne | s |||| 0|eng d |
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|a 9789400774230
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| 024 |
7 |
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|a 10.1007/978-94-007-7423-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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|a G Protein-Coupled Receptors - Modeling and Simulation /
|c edited by Marta Filizola.
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| 250 |
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|a 1st ed. 2014.
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| 260 |
# |
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|a Dordrecht :
|b Springer Netherlands :
|b Imprint: Springer,
|c 2014.
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| 300 |
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|a VIII, 228 p. 59 illus., 45 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Advances in Experimental Medicine and Biology,
|v 796
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|a Preface. Section I Progress in Structural Modeling of GPCRs -- The GPCR Crystallography Boom: Providing an Invaluable Source of Structural Information and Expanding the Scope of Homology Modeling -- Modeling of G Protein-Coupled Receptors Using Crystal Structures: From Monomers to Signaling Complexes. Section II. GPCRs in Motion: Insights from Simulations -- Structure and Dynamics of G Protein-Coupled Receptors -- How the Dynamic Properties and Functional Mechanisms of GPCRs are Modulated by their Coupling to the Membrane Environment -- Coarse-Grained Molecular Dynamics Provides Insight into the Interactions of Lipids and Cholesterol with Rhodopsin -- Beyond Standard Molecular Dynamics: Investigating the Molecular Mechanisms of G Protein-Coupled Receptors with Enhanced Molecular Dynamics Methods. Section III. GPCR-Focused Rational Design and Mathematical Modeling -- From Three-Dimensional GPCR Structure to Rational Ligand Discovery -- Mathematical Modeling Of G Protein-Coupled Receptor Function: What Can We Learn From Empirical And Mechanistic Models? Section IV. Bioinformatics Tools and Resources for GPCRs -- GPCRs & Company: Databases and Servers for GPCRs and Interacting Partners -- Bioinformatics Tools for Predicting GPCR Gene Functions. Index.
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| 650 |
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|a Proteins .
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| 650 |
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|a Medical genetics.
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| 650 |
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|a Biomathematics.
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| 650 |
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4 |
|a Protein Structure.
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| 650 |
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4 |
|a Gene Function.
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| 650 |
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4 |
|a Physiological, Cellular and Medical Topics.
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| 700 |
1 |
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|a Filizola, Marta.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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