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02956nam a22002775i 4500 |
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20210722104303.0 |
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cr nn 008mamaa |
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161206s2017 xxu| s |||| 0|eng d |
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|a 9781493965632
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| 024 |
7 |
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|a 10.1007/978-1-4939-6563-2
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Drug Target miRNA :
|b Methods and Protocols /
|c edited by Marco F. Schmidt.
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| 250 |
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|a 1st ed. 2017.
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| 260 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2017.
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| 300 |
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|a XI, 319 p. 94 illus., 62 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Methods in Molecular Biology,
|v 1517
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| 505 |
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|a MiRNA Targeting Drugs: The Next Blockbusters? -- Functional Analysis of miRNA using DIANA Tools Online Suite -- Non-Nucleotide Modification of Anti-miRNA Oligonucleotides -- Quantification of Oligonucleotide Association with miRNA-Argonaute Complexes In Vitro -- Determination of Anti-miR Association with miRNA/Argonaute Complexes In Vivo -- Competitive Argonaute-Based RNA Immunoprecipitation for Investigation of Transcriptomic Response to Anti-miR -- Assessing Anti-miR Pharmacology with miRNA Polysome Shift Assay -- Evaluating Synergistic Effects of miR-34a Mimics in Combination with Other Therapeutic Agents in Cultured Non-Small Cell Lung Cancer Cells -- Assessing the Off-Target Effects of miRNA Inhibitors on Innate Immune Toll-Like Receptors -- Design of Multimodal Small Molecules Targeting miRNA Biogenesis: Synthesis and In Vitro Evaluation -- Machine Learning Approaches towards Building Predictive Models for Small Molecule Modulators of miRNA and its Utility in Virtual Screening of Molecular Databases -- Identification of Small Molecule Modulators of MicroRNA by Library Screening -- Rapid Generation of miRNA Inhibitor Leads by Bio-Informatics and Efficient High-Throughput Screening Methods -- Peptide-Based Inhibition of miRNA-Guided Gene Silencing -- Small Molecules Targeting the miRNA Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation -- Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders -- Antagonists of the miRNA-Argonaute 2 Protein Complex: Anti-miR-AGOs -- Elucidating Mechanisms of Molecular Recognition between Human Argonaute and miRNA using Computational Approaches -- Kinetic Analysis of Target RNA Binding and Slicing by Argonaute 2 Protein -- Site-Specific Fluorescent Labeling of Argonaute for FRET-Based Bio-Assays -- Single-Molecule Fluorescence Energy Transfer Assays for the Characterization of Reaction Pathways of miRNA-Argonaute Complex.
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| 650 |
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|a Pharmacology.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 700 |
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|a Schmidt, Marco F.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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