Drug Target miRNA : Methods and Protocols /
| Autor Corporativo: | |
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| Otros Autores: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
New York, NY :
Springer New York : Imprint: Humana,
2017.
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| Edición: | 1st ed. 2017. |
| Colección: | Methods in Molecular Biology,
1517 |
| Materias: |
Tabla de Contenidos:
- MiRNA Targeting Drugs: The Next Blockbusters?
- Functional Analysis of miRNA using DIANA Tools Online Suite
- Non-Nucleotide Modification of Anti-miRNA Oligonucleotides
- Quantification of Oligonucleotide Association with miRNA-Argonaute Complexes In Vitro
- Determination of Anti-miR Association with miRNA/Argonaute Complexes In Vivo
- Competitive Argonaute-Based RNA Immunoprecipitation for Investigation of Transcriptomic Response to Anti-miR
- Assessing Anti-miR Pharmacology with miRNA Polysome Shift Assay
- Evaluating Synergistic Effects of miR-34a Mimics in Combination with Other Therapeutic Agents in Cultured Non-Small Cell Lung Cancer Cells
- Assessing the Off-Target Effects of miRNA Inhibitors on Innate Immune Toll-Like Receptors
- Design of Multimodal Small Molecules Targeting miRNA Biogenesis: Synthesis and In Vitro Evaluation
- Machine Learning Approaches towards Building Predictive Models for Small Molecule Modulators of miRNA and its Utility in Virtual Screening of Molecular Databases
- Identification of Small Molecule Modulators of MicroRNA by Library Screening
- Rapid Generation of miRNA Inhibitor Leads by Bio-Informatics and Efficient High-Throughput Screening Methods
- Peptide-Based Inhibition of miRNA-Guided Gene Silencing
- Small Molecules Targeting the miRNA Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation
- Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders
- Antagonists of the miRNA-Argonaute 2 Protein Complex: Anti-miR-AGOs
- Elucidating Mechanisms of Molecular Recognition between Human Argonaute and miRNA using Computational Approaches
- Kinetic Analysis of Target RNA Binding and Slicing by Argonaute 2 Protein
- Site-Specific Fluorescent Labeling of Argonaute for FRET-Based Bio-Assays
- Single-Molecule Fluorescence Energy Transfer Assays for the Characterization of Reaction Pathways of miRNA-Argonaute Complex.