|
|
|
|
LEADER |
03183nam a22003375i 4500 |
001 |
000281547 |
005 |
20210720093837.0 |
007 |
cr nn 008mamaa |
008 |
131203s2014 xxu| s |||| 0|eng d |
020 |
|
|
|a 9781461491057
|
024 |
7 |
|
|a 10.1007/978-1-4614-9105-7
|2 doi
|
040 |
|
|
|a Sistema de Bibliotecas del Tecnológico de Costa Rica
|
245 |
1 |
0 |
|a Drug Delivery to the Brain :
|b Physiological Concepts, Methodologies and Approaches /
|c edited by Margareta Hammarlund-Udenaes, Elizabeth C.M. de Lange, Robert G. Thorne.
|
250 |
|
|
|a 1st ed. 2014.
|
260 |
# |
# |
|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2014.
|
300 |
|
|
|a XX, 731 p. 150 illus., 126 illus. in color. :
|b online resource.
|
336 |
|
|
|a text
|b txt
|2 rdacontent
|
337 |
|
|
|a computer
|b c
|2 rdamedia
|
338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
490 |
1 |
|
|a AAPS Advances in the Pharmaceutical Sciences Series,
|v 10
|
505 |
0 |
|
|a Anatomy and physiology of the blood-brain barriers -- Recent Progress in Blood-Brain Barrier and Blood-CSF Barrier Transport Research: Pharmaceutical Relevance for Drug Delivery to the Brain -- Blood-Brain Barrier (BBB) Pharmacoproteomics: A New Research Field Opened up by Quantitative Targeted Absolute Proteomics (QTAP) -- Drug Metabolism at the Blood-Brain and Blood-CSF Barriers -- Pharmacokinetic Concepts in Brain Drug Delivery -- In vitro models of blood-brain barriers -- In situ and in vivo animal models -- Principles of PET and its Role in Understanding Drug Delivery to the Brain -- PKPD Aspects of Brain Drug Delivery in a Translational Perspective -- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution -- Prediction of Drug Exposure in the Brain from the Chemical Structure -- Integrated Approach to Optimizing CNS Penetration in Drug Discovery: From the old to the new Paradigm and Assessment of Drug-Transporter Interactions -- Pharmacoeconomic Considerations in CNS Drug Development -- Intranasal Drug Delivery to the Brain -- Blood-To-Brain Drug Delivery using Nanocarriers -- Development of new Protein Vectors for the Physiologic Delivery of Large Therapeutic Compounds to the CNS- CNS Gene Therapy Utilizing Intravenously Administered Viral Vectors -- Neurosurgical Approaches: Drug Infusion Directly into the Parenchyma or Cerebrospinal Fluid -- Osmotic Opening of the BBB for Drug Treatment of Brain Tumors (Focus on Methodological Issues) -- Emerging Engineering Technologies for Opening the BBB -- Disease Influence on BBB Transport in Inflammatory Disorders -- Disease Influence on BBB Transport in Neurodegenerative Disorders -- Drug Delivery in the Context of Stroke and Brain Trauma -- Which Drug or Drug Delivery Method can change Clinical Practice for Brain Tumor Therapy?.
|
650 |
|
0 |
|a Pharmaceutical technology.
|
650 |
|
0 |
|a Medicine.
|
650 |
1 |
4 |
|a Pharmaceutical Sciences/Technology.
|
650 |
2 |
4 |
|a Biomedicine, general.
|
700 |
1 |
|
|a Hammarlund-Udenaes, Margareta.
|e editor.
|
700 |
1 |
|
|a de Lange, Elizabeth C.M.
|e editor.
|
700 |
1 |
|
|a Thorne, Robert G.
|e editor.
|
710 |
2 |
|
|a SpringerLink (Online service)
|
773 |
0 |
|
|t Springer eBooks
|
900 |
|
|
|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|