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| LEADER |
03183nam a22003375i 4500 |
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000281547 |
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20210720093837.0 |
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cr nn 008mamaa |
| 008 |
131203s2014 xxu| s |||| 0|eng d |
| 020 |
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|a 9781461491057
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| 024 |
7 |
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|a 10.1007/978-1-4614-9105-7
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Drug Delivery to the Brain :
|b Physiological Concepts, Methodologies and Approaches /
|c edited by Margareta Hammarlund-Udenaes, Elizabeth C.M. de Lange, Robert G. Thorne.
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| 250 |
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|a 1st ed. 2014.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2014.
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| 300 |
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|a XX, 731 p. 150 illus., 126 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a AAPS Advances in the Pharmaceutical Sciences Series,
|v 10
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| 505 |
0 |
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|a Anatomy and physiology of the blood-brain barriers -- Recent Progress in Blood-Brain Barrier and Blood-CSF Barrier Transport Research: Pharmaceutical Relevance for Drug Delivery to the Brain -- Blood-Brain Barrier (BBB) Pharmacoproteomics: A New Research Field Opened up by Quantitative Targeted Absolute Proteomics (QTAP) -- Drug Metabolism at the Blood-Brain and Blood-CSF Barriers -- Pharmacokinetic Concepts in Brain Drug Delivery -- In vitro models of blood-brain barriers -- In situ and in vivo animal models -- Principles of PET and its Role in Understanding Drug Delivery to the Brain -- PKPD Aspects of Brain Drug Delivery in a Translational Perspective -- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution -- Prediction of Drug Exposure in the Brain from the Chemical Structure -- Integrated Approach to Optimizing CNS Penetration in Drug Discovery: From the old to the new Paradigm and Assessment of Drug-Transporter Interactions -- Pharmacoeconomic Considerations in CNS Drug Development -- Intranasal Drug Delivery to the Brain -- Blood-To-Brain Drug Delivery using Nanocarriers -- Development of new Protein Vectors for the Physiologic Delivery of Large Therapeutic Compounds to the CNS- CNS Gene Therapy Utilizing Intravenously Administered Viral Vectors -- Neurosurgical Approaches: Drug Infusion Directly into the Parenchyma or Cerebrospinal Fluid -- Osmotic Opening of the BBB for Drug Treatment of Brain Tumors (Focus on Methodological Issues) -- Emerging Engineering Technologies for Opening the BBB -- Disease Influence on BBB Transport in Inflammatory Disorders -- Disease Influence on BBB Transport in Neurodegenerative Disorders -- Drug Delivery in the Context of Stroke and Brain Trauma -- Which Drug or Drug Delivery Method can change Clinical Practice for Brain Tumor Therapy?.
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| 650 |
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0 |
|a Pharmaceutical technology.
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| 650 |
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0 |
|a Medicine.
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| 650 |
1 |
4 |
|a Pharmaceutical Sciences/Technology.
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| 650 |
2 |
4 |
|a Biomedicine, general.
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| 700 |
1 |
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|a Hammarlund-Udenaes, Margareta.
|e editor.
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| 700 |
1 |
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|a de Lange, Elizabeth C.M.
|e editor.
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| 700 |
1 |
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|a Thorne, Robert G.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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