Drug Delivery to the Brain : Physiological Concepts, Methodologies and Approaches /
| Autor Corporativo: | |
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| Otros Autores: | , , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
New York, NY :
Springer New York : Imprint: Springer,
2014.
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| Edición: | 1st ed. 2014. |
| Colección: | AAPS Advances in the Pharmaceutical Sciences Series,
10 |
| Materias: |
Tabla de Contenidos:
- Anatomy and physiology of the blood-brain barriers
- Recent Progress in Blood-Brain Barrier and Blood-CSF Barrier Transport Research: Pharmaceutical Relevance for Drug Delivery to the Brain
- Blood-Brain Barrier (BBB) Pharmacoproteomics: A New Research Field Opened up by Quantitative Targeted Absolute Proteomics (QTAP)
- Drug Metabolism at the Blood-Brain and Blood-CSF Barriers
- Pharmacokinetic Concepts in Brain Drug Delivery
- In vitro models of blood-brain barriers
- In situ and in vivo animal models
- Principles of PET and its Role in Understanding Drug Delivery to the Brain
- PKPD Aspects of Brain Drug Delivery in a Translational Perspective
- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution
- Prediction of Drug Exposure in the Brain from the Chemical Structure
- Integrated Approach to Optimizing CNS Penetration in Drug Discovery: From the old to the new Paradigm and Assessment of Drug-Transporter Interactions
- Pharmacoeconomic Considerations in CNS Drug Development
- Intranasal Drug Delivery to the Brain
- Blood-To-Brain Drug Delivery using Nanocarriers
- Development of new Protein Vectors for the Physiologic Delivery of Large Therapeutic Compounds to the CNS- CNS Gene Therapy Utilizing Intravenously Administered Viral Vectors
- Neurosurgical Approaches: Drug Infusion Directly into the Parenchyma or Cerebrospinal Fluid
- Osmotic Opening of the BBB for Drug Treatment of Brain Tumors (Focus on Methodological Issues)
- Emerging Engineering Technologies for Opening the BBB
- Disease Influence on BBB Transport in Inflammatory Disorders
- Disease Influence on BBB Transport in Neurodegenerative Disorders
- Drug Delivery in the Context of Stroke and Brain Trauma
- Which Drug or Drug Delivery Method can change Clinical Practice for Brain Tumor Therapy?.