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| LEADER |
01609nam a22003135i 4500 |
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000281642 |
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20210721132832.0 |
| 007 |
cr nn 008mamaa |
| 008 |
151102s2015 gw | s |||| 0|eng d |
| 020 |
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|a 9783319220840
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| 024 |
7 |
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|a 10.1007/978-3-319-22084-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Genotoxicity and Carcinogenicity Testing of Pharmaceuticals /
|c edited by Michael J. Graziano, David Jacobson-Kram.
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| 250 |
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|a 1st ed. 2015.
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| 260 |
# |
# |
|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2015.
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| 300 |
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|a X, 206 p. 15 illus., 8 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 505 |
0 |
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|a Introduction -- History and Current Regulatory Requirements -- Genotoxicity Testing of API and Impurities -- New Emerging Genotoxicity Tests -- Carcinogenicity Testing of Small Molecules -- Alternatives to the 2-Year Rodent Studies -- Addressing Positive Findings in Carcinogenicity Studies -- Investigating Tumor Signals in Clinical Trials -- Tumor Promoters -- Carcinogenicity Testing of Biologics -- In Silico Predictive Tests.
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| 650 |
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0 |
|a Cancer research.
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| 650 |
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0 |
|a Pharmaceutical technology.
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| 650 |
1 |
4 |
|a Cancer Research.
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| 650 |
2 |
4 |
|a Pharmaceutical Sciences/Technology.
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| 700 |
1 |
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|a Graziano, Michael J.
|e editor.
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| 700 |
1 |
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|a Jacobson-Kram, David.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|