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100803s2010 xxu| s |||| 0|eng d |
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|a 9781607617532
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| 024 |
7 |
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|a 10.1007/978-1-60761-753-2
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Engineered Zinc Finger Proteins :
|b Methods and Protocols /
|c edited by Joel P. Mackay, David J. Segal.
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| 250 |
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|a 1st ed. 2010.
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| 260 |
# |
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|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2010.
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| 300 |
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|a XIV, 440 p. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Methods in Molecular Biology,
|v 649
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| 505 |
0 |
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|a Engineering Zinc Finger Proteins -- The Generation of Zinc Finger Proteins by Modular Assembly -- Engineering Single Cys2His2 Zinc Finger Domains Using a Bacterial Cell-Based Two-Hybrid Selection System -- Bipartite Selection of Zinc Fingers by Phage Display for Any 9-bp DNA Target Site -- Structure-Based DNA-Binding Prediction and Design -- Artificial Transcription Factors -- Generation of Cell-Permeable Artificial Zinc Finger Protein Variants -- Inhibition of Viral Transcription Using Designed Zinc Finger Proteins -- Modulation of Gene Expression Using Zinc Finger-Based Artificial Transcription Factors -- Construction of Combinatorial Libraries that Encode Zinc Finger-Based Transcription Factors -- Silencing of Gene Expression by Targeted DNA Methylation: Concepts and Approaches -- Remodeling Genomes with Artificial Transcription Factors (ATFs) -- Transgenic Mice Expressing an Artificial Zinc Finger Regulator Targeting an Endogenous Gene -- Zinc Finger Nucleases -- Artificial Zinc Finger Nucleases for DNA Cloning -- In Vitro Assessment of Zinc Finger Nuclease Activity -- Quantification of Zinc Finger Nuclease-Associated Toxicity -- A Rapid and General Assay for Monitoring Endogenous Gene Modification -- Engineered Zinc Finger Proteins for Manipulation of the Human Mitochondrial Genome -- High-Efficiency Gene Targeting in Drosophila with Zinc Finger Nucleases -- Using Zinc Finger Nucleases for Efficient and Heritable Gene Disruption in Zebrafish -- A Transient Assay for Monitoring Zinc Finger Nuclease Activity at Endogenous Plant Gene Targets -- Validation and Expression of Zinc Finger Nucleases in Plant Cells -- Non-FokI-Based Zinc Finger Nucleases -- Beyond Transcription and Cleavage -- Designing and Testing Chimeric Zinc Finger Transposases -- Seeing Genetic and Epigenetic Information Without DNA Denaturation Using Sequence-Enabled Reassembly (SEER) -- Zinc Finger-Mediated Live Cell Imaging in Arabidopsis Roots -- Biophysical Analysis of the Interaction of Toxic Metal Ions and Oxidants with the Zinc Finger Domain of XPA -- Preparation and Zinc-Binding Properties of Multi-Fingered Zinc-Sensing Domains -- Using ChIP-seq Technology to Identify Targets of Zinc Finger Transcription Factors -- Crystallization of Zinc Finger Proteins Bound to DNA -- Beyond DNA: Zinc Finger Domains as RNA-Binding Modules.
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| 650 |
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0 |
|a Proteins .
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| 650 |
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0 |
|a Genetic engineering.
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| 650 |
1 |
4 |
|a Protein Science.
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| 650 |
2 |
4 |
|a Genetic Engineering.
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| 700 |
1 |
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|a Mackay, Joel P.
|e editor.
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| 700 |
1 |
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|a Segal, David J.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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