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150731s2016 xxu| s |||| 0|eng d |
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|a 9781493929269
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| 024 |
7 |
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|a 10.1007/978-1-4939-2926-9
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Cyclin-Dependent Kinase (CDK) Inhibitors :
|b Methods and Protocols /
|c edited by Mar Orzáez, Mónica Sancho Medina, Enrique Pérez-Payá.
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| 250 |
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|a 1st ed. 2016.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2016.
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| 300 |
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|a X, 227 p. 42 illus., 22 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1336
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| 505 |
0 |
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|a Immunoprecipitation of CDK-Cyclin Complexes for Determination of Kinase Activity -- Expression and Purification of Recombinant Cyclins and CDKs for Activity Evaluation -- Expression and Purification of Recombinant CDKs: CDK7, CDK8 and CDK9 -- Preparation of CDK/Cyclin Inhibitor Complexes for Structural Determination -- Fragment-Based De Novo Design of Cyclin-Dependent Kinase 2 Inhibitors -- Protein-Protein Interaction Inspire the De Novo Design of Cyclin-Dependent Kinases Peptide Inhibitors -- Identification of Cyclin A Binders with a Fluorescent Peptide Sensor -- Cell Synchronization Techniques to Study the Action of CDK Inhibitors -- Analysis of CDK Inhibitors Action on Mitochondria-Mediated Apoptosis -- Evaluating the Effects of CDK Inhibitors in Ischemia-Reperfusion Injury Models -- Assessing Cell Cycle Independent Function of the CDK Inhibitor p21CDKN1A in DNA Repair -- Drug Delivery Strategies of Chemical CDK Inhibitors -- Animal Models for Studying the In Vivo Functions of Cell Cycle CDKs -- Evaluating Chemical CDK Inhibitors as Cell Death Inducers -- Models for the Study of the Crosstalk between Inflammation and Cell Cycle -- Metabolomic Applications to the Characterization of the Mode-of-Action of CDK Inhibitors.
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| 650 |
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0 |
|a Pharmacology.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 700 |
1 |
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|a Orzáez, Mar.
|e editor.
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| 700 |
1 |
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|a Sancho Medina, Mónica.
|e editor.
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| 700 |
1 |
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|a Pérez-Payá, Enrique.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
|