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02657nam a22002775i 4500 |
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20210728123525.0 |
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cr nn 008mamaa |
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170726s2017 xxu| s |||| 0|eng d |
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|a 9781493971725
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| 024 |
7 |
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|a 10.1007/978-1-4939-7172-5
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Drug Safety Evaluation :
|b Methods and Protocols /
|c edited by Jean-Charles Gautier.
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| 250 |
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|a 2nd ed. 2017.
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| 260 |
# |
# |
|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2017.
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| 300 |
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|a XI, 427 p. 58 illus., 28 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1641
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| 505 |
0 |
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|a Nonclinical Development of Combination Drugs -- Juvenile Non-Clinical Safety Studies in Support of Pediatric Drug Development -- Procedures of Necropsy and Tissue Sampling -- Tissue Sampling and Processing for Histopathology Evaluation -- Principles and Methods of Immunohistochemistry -- Applications of Mass Spectrometry Imaging for Safety Evaluation -- In vivo rat T-lymphocyte Pig-a assay: detection and expansion of cells deficient in the GPI-anchored CD48 surface marker for analysis of mutation in the endogenous Pig-a gene -- Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids -- The Use of Bacterial Repair Endonucleases in the Comet Assay -- Automated Patch-Clamp methods for the hERG Cardiac Potassium Channel -- Impedance Measurement in Induced Pluripotent Stem Cell Derived Cardiomyocytes -- Target Safety Assessment: Strategies and Resources -- NMR and MS Methods for Metabolomics -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR -- Statistical Analysis of Quantitative RT-PCR Results -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes -- FETAX Assay for Evaluation of Developmental Toxicity -- Evaluation of Embryotoxicity Using the Zebrafish Model -- Absolute Quantification of Toxicological Biomarkers via Mass Spectrometry -- Next-Generation Sequencing to investigate urinary microRNAs from Macaca fascicularis (Cynomolgus Monkey) -- Quantitative RT-PCR for MicroRNAs in Biofluids -- Chromogenic In Situ Hybridization Methods for microRNA Biomarker Monitoring of Drug Safety and Efficacy -- Urine Exosome Isolation and Characterization.
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| 650 |
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|a Pharmacology.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 700 |
1 |
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|a Gautier, Jean-Charles.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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