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121205s2009 xxu| s |||| 0|eng d |
| 020 |
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|a 9781603273176
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| 024 |
7 |
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|a 10.1007/978-1-60327-317-6
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a G Protein-Coupled Receptors in Drug Discovery /
|c edited by Wayne R. Leifert.
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| 250 |
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|a 1st ed. 2009.
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| 260 |
# |
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|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2009.
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| 300 |
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|a XII, 376 p. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 552
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| 505 |
0 |
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|a New Insights into GPCR Function: Implications for HTS -- Screening Technologies for G Protein-Coupled Receptors: From HTS to uHTS -- GPCR Signaling: Understanding the Pathway to Successful Drug Discovery -- An Overview on GPCRs and Drug Discovery: Structure-Based Drug Design and Structural Biology on GPCRs -- Understanding the Ligand–Receptor–G Protein Ternary Complex for GPCR Drug Discovery -- Assay Data Quality Assessment -- Homology Modeling of GPCRs -- GPCR Expression Using Baculovirus-Infected Sf9 Cells -- Radioligand Binding Assays: Application of [125I]Angiotensin II Receptor Binding -- [35S]GTP?S Binding in G Protein-Coupled Receptor Assays -- A Time-Resolved Fluorescent Lanthanide (Eu)-GTP Binding Assay for Chemokine Receptors as Targets in Drug Discovery -- Use of the DiscoveRx Hithunter cAMPII Assay for Direct Measurement of cAMP in Gs and Gi GPCRs -- Use of Aequorin for G protein-Coupled Receptor Hit Identification and Compound Profiling -- BacMam: Versatile Gene Delivery Technology for GPCR Assays -- Yeast Assays for G Protein-Coupled Receptors -- GPCR Microspot Assays on Solid Substrates -- Resonant Waveguide Grating Biosensor for Whole-Cell GPCR Assays -- FRET-Based Measurement of GPCR Conformational Changes -- FLIPR® Assays of Intracellular Calcium in GPCR Drug Discovery -- Use of Fluorescence Indicators in Receptor Ligands -- Application of Fluorescence Resonance Energy Transfer Techniques to Establish Ligand–Receptor Orientation -- Detection of GPCR/?-Arrestin Interactions in Live Cells Using Bioluminescence Resonance Energy Transfer Technology -- Using Reporter Gene Technologies to Detect Changes in cAMP as a Result of GPCR Activation -- A Quantum Dot-Labeled Ligand–Receptor Binding Assay for G Protein-Coupled Receptors Contained in Minimally Purified Membrane Nanopatches -- Xenopus Oocyte Electrophysiology in GPCR Drug Discovery -- Immunoprecipitation and Phosphorylation of G Protein-Coupled Receptors.
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| 650 |
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|a Pharmacology.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 700 |
1 |
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|a Leifert, Wayne R.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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