G Protein-Coupled Receptors in Drug Discovery /
| Autor Corporativo: | |
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| Otros Autores: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2009.
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| Edición: | 1st ed. 2009. |
| Colección: | Methods in Molecular Biology,
552 |
| Materias: |
Tabla de Contenidos:
- New Insights into GPCR Function: Implications for HTS
- Screening Technologies for G Protein-Coupled Receptors: From HTS to uHTS
- GPCR Signaling: Understanding the Pathway to Successful Drug Discovery
- An Overview on GPCRs and Drug Discovery: Structure-Based Drug Design and Structural Biology on GPCRs
- Understanding the Ligand–Receptor–G Protein Ternary Complex for GPCR Drug Discovery
- Assay Data Quality Assessment
- Homology Modeling of GPCRs
- GPCR Expression Using Baculovirus-Infected Sf9 Cells
- Radioligand Binding Assays: Application of [125I]Angiotensin II Receptor Binding
- [35S]GTP?S Binding in G Protein-Coupled Receptor Assays
- A Time-Resolved Fluorescent Lanthanide (Eu)-GTP Binding Assay for Chemokine Receptors as Targets in Drug Discovery
- Use of the DiscoveRx Hithunter cAMPII Assay for Direct Measurement of cAMP in Gs and Gi GPCRs
- Use of Aequorin for G protein-Coupled Receptor Hit Identification and Compound Profiling
- BacMam: Versatile Gene Delivery Technology for GPCR Assays
- Yeast Assays for G Protein-Coupled Receptors
- GPCR Microspot Assays on Solid Substrates
- Resonant Waveguide Grating Biosensor for Whole-Cell GPCR Assays
- FRET-Based Measurement of GPCR Conformational Changes
- FLIPR® Assays of Intracellular Calcium in GPCR Drug Discovery
- Use of Fluorescence Indicators in Receptor Ligands
- Application of Fluorescence Resonance Energy Transfer Techniques to Establish Ligand–Receptor Orientation
- Detection of GPCR/?-Arrestin Interactions in Live Cells Using Bioluminescence Resonance Energy Transfer Technology
- Using Reporter Gene Technologies to Detect Changes in cAMP as a Result of GPCR Activation
- A Quantum Dot-Labeled Ligand–Receptor Binding Assay for G Protein-Coupled Receptors Contained in Minimally Purified Membrane Nanopatches
- Xenopus Oocyte Electrophysiology in GPCR Drug Discovery
- Immunoprecipitation and Phosphorylation of G Protein-Coupled Receptors.