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03752nam a22003135i 4500 |
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000283927 |
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20210812145226.0 |
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cr nn 008mamaa |
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150615s2015 xxu| s |||| 0|eng d |
| 020 |
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|a 9781493926817
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| 024 |
7 |
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|a 10.1007/978-1-4939-2681-7
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development /
|c edited by Steven J. Potts, David A. Eberhard, Keith A. Wharton, Jr.
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| 250 |
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|a 1st ed. 2015.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2015.
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| 300 |
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|a XVIII, 375 p. 57 illus., 37 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Pharmacology and Toxicology,
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| 505 |
0 |
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|a Histopathology: A Canvas and Landscape of Disease in Drug and Diagnostic Development -- A Field Guide to Homo morphologicus for Biomedical Scientists, Or How to Convey an Understanding of Pathology to Scientists in a Biopharma Enterprise -- Outsourcing Tissue Histopathology Investigations in Support of Clinical Trials for Novel Therapeutics: Considerations and Perspectives -- Histopathology in Mouse Models of Rheumatoid Arthritis -- Markers Used for Visualization and Quantification of Blood Vessels and Lymphatic Vessels -- Practical Approaches to Microvessel Analysis: Hotspots, Microvessel Density, and Vessel Proximity -- Quantitative Histopathology and Alternative Approaches to Assessment of Fibrosis for Drug Development in Hepatitis C and Nonalcoholic Steatohepatitis -- Stereology and Computer-Based Image Analysis Quantifies Heterogeneity and Improves Reproducibility for Grading Reticulin in Myeloproliferative Neoplasms -- Image Analysis Tools for Quantification of Spinal Motor Neuron Subtype Identities -- Development of a Tissue Image Analysis Algorithm for Celiac Drug Development -- Quantitative Histopathology for Evaluation of In Vivo Biocompatibility Associated with Biomedical Implants -- Quantitative Histomorphometry and Quantitative Polymerase Chain Reaction (PCR) as Assessment Tools for Product Development -- Measuring the Messenger: RNA Histology in Formalin Fixed Tissues -- Algorithm-Driven Image Analysis Solutions for RNA ISH Quantification in Human Clinical Tissues -- Solid Tissue-Based DNA Analysis by FISH in Research and Molecular Diagnostics -- Preanalytic Considerations for Molecular Genomic Analyses of Tissue -- Next Generation Sequencing (NGS) in Anatomic Pathology Discovery and Practice -- The Impact of Pre-Analytic Variables on Tissue Quality from Clinical Samples Collected in a Routine Clinical Setting: Implications for Diagnostic Evaluation, Drug Discovery, and Translational Research -- Adapting HER2 Testing for a Different Organ: New Wine in Old Wineskins -- Tissue-Based Companion Diagnostics: Development of IHC Assays from an Industry Perspective -- Development of Tissue-Based Companion Diagnostics: The Relationship Between the Pharmaceutical Company, Diagnostic Partner, and the Biomarker Laboratory -- Navigating Regulatory Approval for Tissue-Based Companion Diagnostics -- Implementing a Multi-Analyte Immunohistochemistry Panel into a Drug Development Program -- Cutpoint Analysis and Related Statistical Methods in Digital Pathology and Companion Diagnostics.
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| 650 |
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0 |
|a Pharmacology.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 700 |
1 |
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|a Potts, Steven J.
|e editor.
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| 700 |
1 |
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|a Eberhard, David A.
|e editor.
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| 700 |
1 |
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|a Wharton, Jr., Keith A.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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