Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development /

Detalles Bibliográficos
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Potts, Steven J. (Editor ), Eberhard, David A. (Editor ), Wharton, Jr., Keith A. (Editor )
Formato: eBook
Lenguaje:English
Publicado: New York, NY : Springer New York : Imprint: Humana, 2015.
Edición:1st ed. 2015.
Colección:Methods in Pharmacology and Toxicology,
Materias:
Tabla de Contenidos:
  • Histopathology: A Canvas and Landscape of Disease in Drug and Diagnostic Development
  • A Field Guide to Homo morphologicus for Biomedical Scientists, Or How to Convey an Understanding of Pathology to Scientists in a Biopharma Enterprise
  • Outsourcing Tissue Histopathology Investigations in Support of Clinical Trials for Novel Therapeutics: Considerations and Perspectives
  • Histopathology in Mouse Models of Rheumatoid Arthritis
  • Markers Used for Visualization and Quantification of Blood Vessels and Lymphatic Vessels
  • Practical Approaches to Microvessel Analysis: Hotspots, Microvessel Density, and Vessel Proximity
  • Quantitative Histopathology and Alternative Approaches to Assessment of Fibrosis for Drug Development in Hepatitis C and Nonalcoholic Steatohepatitis
  • Stereology and Computer-Based Image Analysis Quantifies Heterogeneity and Improves Reproducibility for Grading Reticulin in Myeloproliferative Neoplasms
  • Image Analysis Tools for Quantification of Spinal Motor Neuron Subtype Identities
  • Development of a Tissue Image Analysis Algorithm for Celiac Drug Development
  • Quantitative Histopathology for Evaluation of In Vivo Biocompatibility Associated with Biomedical Implants
  • Quantitative Histomorphometry and Quantitative Polymerase Chain Reaction (PCR) as Assessment Tools for Product Development
  • Measuring the Messenger: RNA Histology in Formalin Fixed Tissues
  • Algorithm-Driven Image Analysis Solutions for RNA ISH Quantification in Human Clinical Tissues
  • Solid Tissue-Based DNA Analysis by FISH in Research and Molecular Diagnostics
  • Preanalytic Considerations for Molecular Genomic Analyses of Tissue
  • Next Generation Sequencing (NGS) in Anatomic Pathology Discovery and Practice
  • The Impact of Pre-Analytic Variables on Tissue Quality from Clinical Samples Collected in a Routine Clinical Setting: Implications for Diagnostic Evaluation, Drug Discovery, and Translational Research
  • Adapting HER2 Testing for a Different Organ: New Wine in Old Wineskins
  • Tissue-Based Companion Diagnostics:  Development of IHC Assays from an Industry Perspective
  • Development of Tissue-Based Companion Diagnostics:  The Relationship Between the Pharmaceutical Company, Diagnostic Partner, and the Biomarker Laboratory
  • Navigating Regulatory Approval for Tissue-Based Companion Diagnostics
  • Implementing a Multi-Analyte Immunohistochemistry Panel into a Drug Development Program
  • Cutpoint Analysis and Related Statistical Methods in Digital Pathology and Companion Diagnostics.