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20201006150651.0 |
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190206s2019 xxu| s |||| 0|eng d |
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|a 9781493987962
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| 024 |
7 |
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|a 10.1007/978-1-4939-8796-2
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Methionine Dependence of Cancer and Aging :
|b Methods and Protocols /
|c edited by Robert M. Hoffman.
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| 250 |
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|a 1st ed. 2019.
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| 260 |
# |
# |
|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2019.
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| 300 |
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|a XII, 329 p. 80 illus., 34 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1866
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| 505 |
0 |
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|a Methods to Study the Role of Methionine Restricted Diet and Methioninase in Cancer Growth Control -- Altered Methionine Metabolism in Cancer Cells -- Linkage of Methionine-Dependence and Other Features of Malignancy -- Isolation and Characterization of Methionine Independent Clones from Methionine Dependent Cancer Cells -- Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction -- Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction -- Efficacy of Methionine-Restricted Diets on Cancers In Vivo -- Dietary Methionine-Restriction Based Cancer Chemotherapy in Rodents -- Clinical Studies of Methionine-Restricted Diets for Cancer Patients -- Development of Recombinant Methioninase for Cancer Treatment -- Methioninase Cell-Cycle Trap Cancer Chemotherapy -- High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer -- Total Methionine Restriction Treatment of Cancer -- Methioninase Gene Therapy -- Selenomethionine and Methioninase: Selenium Free Radical Anti-Cancer Activity -- Super and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates -- Pilot Phase 1 Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine -- Methionine Gamma Lyase from Clostridium sporogenes Increases the Anti-Cancer Effect of Doxorubicin in A549 Cancer Cells In Vitro and Human Cancer Xenografts -- Methionine Restriction and Life-Span Extension -- L-[methyl-11C] Methionine-Positron Emission Tomography (MET PET) -- Is the Hoffman Effect for Methionine Overuse Analogous to the Warburg Effect for Glucose Overuse in Cancer? -- Recombinant Methioninase as a DNA Demethylation Agent -- Homocysteine, Thioretinaco Ozonide and Oxidative Phosphorylation in Cancer and Aging: A Proposed Clinical Trial Protocol -- Afterword - Oral Methioninase: Answer to Cancer and Foundation of Youth?.
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| 650 |
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|a Cancer research.
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| 650 |
1 |
4 |
|a Cancer Research.
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| 700 |
1 |
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|a Hoffman, Robert M.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|