|
|
|
|
| LEADER |
02771nam a22003975i 4500 |
| 001 |
000284365 |
| 005 |
20210817120931.0 |
| 007 |
cr nn 008mamaa |
| 008 |
150227s2015 ne | s |||| 0|eng d |
| 020 |
|
|
|a 9789401797191
|
| 024 |
7 |
|
|a 10.1007/978-94-017-9719-1
|2 doi
|
| 040 |
|
|
|a Sistema de Bibliotecas del Tecnológico de Costa Rica
|
| 245 |
1 |
0 |
|a Multifaceted Roles of Crystallography in Modern Drug Discovery /
|c edited by Giovanna Scapin, Disha Patel, Eddy Arnold.
|
| 250 |
|
|
|a 1st ed. 2015.
|
| 260 |
# |
# |
|a Dordrecht :
|b Springer Netherlands :
|b Imprint: Springer,
|c 2015.
|
| 300 |
|
|
|a XI, 240 p. 107 illus., 89 illus. in color. :
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a NATO Science for Peace and Security Series A: Chemistry and Biology,
|
| 505 |
0 |
|
|a Preface -- List of Contributors -- Engineering G Protein-Coupled Receptors for Drug Design -- Structural Insights into Activation and Allosteric Modulation of G Protein-Coupled Receptors -- Epigenetic Drug Discovery -- Crystallography and Biopharmaceuticals -- Structural Chemistry and Molecular Modeling in the Design of DPP4 Inhibitors -- Considerations for Structure-Based Drug Design Targeting HIV-1 Reverse Transcriptase.-Protein-Ligand Interactions as the Basis for Drug Action -- The Protein Data Bank: Overview and Tools for Drug Discovery -- Small Molecule Crystal Structures in Drug Discovery -- Protein Aggregation and its Prediction -- Importance of Protonation States for the Binding of Ligands to Pharmaceutical Targets -- Protein-Protein Interactions: Structures and Druggability -- Achieving High Quality Ligand Chemistry in Protein-Ligand Crystal Structures for Drug Design -- Molecular Obesity, Potency and Other Addictions in Drug Discovery -- Adventures in Small Molecule Fragment Screening by X-ray Crystallography for Drug Discovery -- Structure-Based Drug Design to Perturb Function of a tRNA-Modifying Enzyme by Active Site and Protein-Protein Interface Inhibition -- Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function.
|
| 650 |
|
0 |
|a Proteins .
|
| 650 |
|
0 |
|a Medicinal chemistry.
|
| 650 |
|
0 |
|a Molecular biology.
|
| 650 |
|
0 |
|a Chemistry, Physical and theoretical.
|
| 650 |
|
0 |
|a Crystallography.
|
| 650 |
1 |
4 |
|a Protein-Ligand Interactions.
|
| 650 |
2 |
4 |
|a Medicinal Chemistry.
|
| 650 |
2 |
4 |
|a Molecular Medicine.
|
| 650 |
2 |
4 |
|a Theoretical and Computational Chemistry.
|
| 650 |
2 |
4 |
|a Crystallography and Scattering Methods.
|
| 700 |
1 |
|
|a Scapin, Giovanna.
|e editor.
|
| 700 |
1 |
|
|a Patel, Disha.
|e editor.
|
| 700 |
1 |
|
|a Arnold, Eddy.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|