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170328s2017 gw | s |||| 0|eng d |
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|a 9783319499697
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| 024 |
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|a 10.1007/978-3-319-49969-7
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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|a Leucine-Rich Repeat Kinase 2 (LRRK2) /
|c edited by Hardy J. Rideout.
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| 250 |
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|a 1st ed. 2017.
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| 260 |
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2017.
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| 300 |
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|a XVII, 271 p. 27 illus., 17 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Advances in Neurobiology,
|v 14
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|a Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson’s Disease -- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson’s disease -- Clinical features of LRRK2 carriers with Parkinson’s disease -- Part II: Fundamentals of LRRK2 Biology -- LRRK2 phosphorylation -- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity -- LRRK2 and autophagy -- Molecular insights and functional implication of LRRK2 dimerization -- LRRK2 and the immune system -- Regulation of LRRK2 by phosphatases -- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options -- Animal models of LRRK2-associated Parkinson’s disease -- LRRK2 and the “LRRKtosome” at the crossroads of programmed cell death: Clues from RIP kinase relatives -- Interaction of LRRK2 and α-synuclein in Parkinson’s disease -- Mechanisms of mutant LRRK2 neurodegeneration -- Small molecule inhibitors of LRRK2.
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| 650 |
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|a Neurosciences.
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| 650 |
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|a Neurology .
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| 650 |
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4 |
|a Neurosciences.
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| 650 |
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4 |
|a Neurology.
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| 700 |
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|a Rideout, Hardy J.
|e editor.
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| 710 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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