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04979nam a22003735i 4500 |
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150218s2014 xxu| s |||| 0|eng d |
| 020 |
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|a 9781493916559
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| 024 |
7 |
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|a 10.1007/978-1-4939-1655-9
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Humanized Mice for HIV Research /
|c edited by Larisa Y. Poluektova, J. Victor Garcia, Yoshio Koyanagi, Markus G. Manz, Andrew M. Tager.
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| 250 |
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|a 1st ed. 2014.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2014.
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| 300 |
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|a XXI, 538 p. 54 illus., 45 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 505 |
0 |
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|a Mamoru Ito's Vision for the Future of Humanized Mouse Models -- Part I. Mouse genetic background and human hematopoietic stem cells biology -- Humanized Mice as Models for Human Disease -- Role of mouse innate immunity in immunodeficient mice for xenotransplantation -- Mouse genetic background and human hematopoietic stem cells biology; tips for humanization -- Biology of Human Hematopoietic Stem Cell Xenotransplantation in Mice -- Impact of the mouse IL-2Rg chain on lymphoid tissue development and human reconstitution in immunodeficient mice -- BM hematopoietic niche occupancy defect of HSC in scid mice -- Improvement of human multilineage hematopoietic engraftment by cytokine knockin replacement in human-hemato-lymphoid system mice -- Part II. SECTION 2: Understanding of human immune cells development and function in mouse environment -- Cytokine species-specificity and humanized mice -- Human T cell biology in a mouse environment -- Thymic education of human T cells and regulatory T cell development in humanized mice -- Human B cell development in a mouse environment -- The analysis of the functions of human B and T cells in humanized NOG mice -- NK cell development in human immune system (HIS) mice and their role in HIV pathogenesis -- Maintenance and function of human CD8+ T cells and NK cells in humanized mice -- Phenotypical and functional properties of antigen-presenting cells derived from humanized mice -- Part III: Humanized mice for HIV-1 virus biology and pathogenesis. Is it possible to address? -- Humanized mouse versus non-human primate models of HIV-1 infection -- Host factor-mediated resistance to HIV-1 infection -- Vaginal and Rectal HIV Transmission in Humanized Mice -- Oral HIV-1 Transmission in BLT Humanized Mice -- Selective infection of CD4+ memory T cells -- Development and function of human CD4+CD25+FOXP3+ regulatory T cells in humanized mouse and HIV-1 infection -- Role of TLR signaling in HIV-1-induced adaptive immune activation -- Latent HIV-1 infection of resting CD4+ T cells: Testing approaches to overcome HIV latency -- Brain HIV-1 infection modeling in humanized mice -- Part IV. Humanized mice for HIV-1-specific adaptive cellular and humoral immune responses -- Antibody-based protection against HIV infection -- B-cell responses in humanized mice: the glass is half full -- Part V. Therapeutics developments for HIV-1 -- Species similarities and differences in pharmacokinetics and distribution of antiretroviral drugs -- Anti-Retroviral Treatment Testing in HIV-Infected Humanized Mice -- Humanized Mice as a Platform for the Development of Long-Acting Nanoformulated Antiretroviral Therapy -- Targeted delivery of aptamers and siRNAs for HIV prevention and therapies in humanized mice -- Zinc finger nuclease editing of hematopoietic stem cells as an anti-HIV therapy -- Hematopoietic progenitor cell transduction by a unique short hairpin RNA to chemokine receptor 5 -- Cell-based approaches for treating HIV infection -- A conditionally replicating human immunodeficiency virus in BRG-HIS mice -- Part VI. New models for other human-specific or human selective pathogens -- Dual reconstituted mice for hepatotropic pathogens -- Dengue viral pathogenesis and immune responses in humanized mice -- HIV-1 and TB: How Humanized Mice Can Help -- Epstein-Barr Virus Infection in Humanized Mice -- HTLV-1 infection of humanized NOD/SCID IL2 gc-/- and BALB/c-Rag2-/-gc-/- mouse models -- Plasmodium falciparum parasite development in humanized mice: liver and blood stages -- Part VII. New horizons in mouse humanization -- The Future is NOW for Humanized Mouse Models.
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| 650 |
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0 |
|a Medical microbiology.
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| 650 |
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0 |
|a Immunology.
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| 650 |
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0 |
|a Virology.
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| 650 |
1 |
4 |
|a Medical Microbiology.
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| 650 |
2 |
4 |
|a Immunology.
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| 650 |
2 |
4 |
|a Virology.
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| 700 |
1 |
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|a Poluektova, Larisa Y.
|e editor.
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| 700 |
1 |
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|a Garcia, J. Victor.
|e editor.
|
| 700 |
1 |
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|a Koyanagi, Yoshio.
|e editor.
|
| 700 |
1 |
|
|a Manz, Markus G.
|e editor.
|
| 700 |
1 |
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|a Tager, Andrew M.
|e editor.
|
| 710 |
2 |
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|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|