High Content Screening : A Powerful Approach to Systems Cell Biology and Phenotypic Drug Discovery /

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Johnston, Paul A. (Editor), Trask, Oscar J. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Humana, 2018.
Edition:2nd ed. 2018.
Series:Methods in Molecular Biology, 1683
Subjects:
Table of Contents:
  • Applications and Caveats on the Utilization of DNA-specific Probes in Cell-based Assays
  • General Staining and Segmentation Procedures for High Content Imaging and Analysis
  • Tools to Measure Cell Health and Cytotoxicity Using High Content Imaging and Analysis
  • Cell-based High Content Analysis of Cell Proliferation and Apoptosis
  • Tools to Measure Autophagy using High Content Imaging and Analysis
  • Guidelines for Microplate Selection in High Content Imaging
  • Quality Control for High-Throughput Imaging Experiments using Machine Learning in CellProfiler
  • High Content Screening Approaches That Minimize Confounding Factors in RNAi, CRISPR and Small Molecule Screening
  • Strategies and solutions to Maintain and Retain Data from High Content Imaging, Analysis, and Screening Assays
  • Live-Cell High Content Screening in Drug Development
  • Challenges and Opportunities in Enabling High-Throughput, Miniaturized High-Content Screening
  • Translocation Biosensors - Versatile Tools to Probe Protein Functions In Living Cells
  • High Content Positional Biosensor Assay to Screen for Compounds that Prevent or Disrupt Androgen Receptor and Transcription Intermediary Factor 2 Protein-Protein Interactions
  • High Content Imaging Assays for IL-6-induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines
  • Single Cell and Population Level Analysis of HCA Data
  • Utilization of Multidimensional Data in the Analysis of Ultra High Throughput High Content Phenotypic Screens
  • High Content Screening of Mammalian Primary Cortical Neurons
  • Human Derived Neurons and Neural Progenitor Cells in High Content Imaging Applications
  • Determination of Hepatotoxicity in iPSC-Derived Hepatocytes by Multiplexed High-Content Assays
  • The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-well Ultra-Low Attachment Microplates
  • An Endothelial Cell/Mesenchymal Stem Cell Co-Culture Cord Formation Assay to Model Vascular Biology In Vitro
  • High-throughput Automated Chemical Screens in Zebrafish.