|
|
|
|
| LEADER |
02146nam a22003735i 4500 |
| 001 |
000287740 |
| 005 |
20210827135309.0 |
| 007 |
cr nn 008mamaa |
| 008 |
160330s2016 gw | s |||| 0|eng d |
| 020 |
|
|
|a 9783319289144
|
| 024 |
7 |
|
|a 10.1007/978-3-319-28914-4
|2 doi
|
| 040 |
|
|
|a Sistema de Bibliotecas del Tecnológico de Costa Rica
|
| 245 |
1 |
0 |
|a New Approaches to Drug Discovery /
|c edited by Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch.
|
| 250 |
|
|
|a 1st ed. 2016.
|
| 260 |
# |
# |
|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2016.
|
| 300 |
|
|
|a VIII, 341 p. 100 illus., 63 illus. in color. :
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a Handbook of Experimental Pharmacology,
|v 232
|
| 505 |
0 |
|
|a Preface -- Part 1. Historical View -- Drug discovery in the past and today.Part 2. Target Discovery -- Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis -- Part 3. Lead generation and Optimization -- Sources for leads: natural products, libraries. Screening: assays, readout, technology. Impact of structural biology, fragment based screening/Virtual screening. Predictive in silico tools of compound properties. High throughput synthesis. New compound classes: Protein-Protein Interaction. Sources for biological leads/Screening of biologicals -- Part 4. Test systems for Efficacy and Safety -- In vitro / Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact of biomarkers/personalized medicine. Simulating in vivo drug effects.
|
| 650 |
|
0 |
|a Pharmacology.
|
| 650 |
|
0 |
|a Pharmacy.
|
| 650 |
|
0 |
|a Medical biochemistry.
|
| 650 |
|
0 |
|a Metabolism.
|
| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
|
| 650 |
2 |
4 |
|a Drug Safety and Pharmacovigilance.
|
| 650 |
2 |
4 |
|a Medical Biochemistry.
|
| 650 |
2 |
4 |
|a Metabolomics.
|
| 700 |
1 |
|
|a Nielsch, Ulrich.
|e editor.
|
| 700 |
1 |
|
|a Fuhrmann, Ulrike.
|e editor.
|
| 700 |
1 |
|
|a Jaroch, Stefan.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|